Anti-COX2 Anticorpo [rCOX2/6996] (A314809)

Anti-COX2 Antibody [rCOX2/6996]

Mouse monoclonal [rCOX2/6996] antibody to COX2.

Prostaglandins are a diverse group of autocrine and paracrine hormones that mediate many cellular and physiologic processes. Prostaglandin H2 (PGH2) is an intermediate molecule in formation of the prostaglandins. Cyclooxygenase-1 (Cox-1) and cyclooxygenase-2 (Cox-2) are prostaglandin synthases that catalyze the formation of PGH2 from arachidonic acid (AA). Cox-1 and Cox-2 are isozymes of prostaglandin-endoperoxidase synthase (PTGS). Cox-1 is constitutively expressed in most tissues and is thought to serve in general housekeeping functions. Cox-2 is efficiently induced in migratory cells responding to pro-inflammatory stimuli and is considered to be an important mediator of inflammation. Both enzymes are targets for the nonsteroidal therapeutic anti-inflammatory drugs, NSAIDs. COX2 expression is significantly increased in 85-90% of human colorectal adenocarcinomas whereas levels of COX-1 are not changed.

IHC-P

Human colon or lung carcinoma.

IHC: 1-2 µg/ml

Human

Recombinant human COX2 protein fragment (around Amino Acids 504-604). The exact sequence is proprietary.

Mouse

Monoclonal

rCOX2/6996

IgG1

Unconjugated

Protein A/G chromatography.

200 µg/ml

70-72 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

COX 2, COX-2, Cyclooxygenase 2, Cyclooxygenase 2b, Cyclooxygenase-2, Glucocorticoid-regulated inframmatory prostagandin G/H synthase, GRIPGHS, hCox 2, PGG/HS, PGH synthase 2, PGH2_HUMAN, PGHS 2, PGHS-2, PGHS2, PHS 2, PHS II, Prostaglandin endoperoxide synthase 2, Prostaglandin endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase), Prostaglandin G/H synthase 2, Prostaglandin G/H synthase and cyclooxygenase, Prostaglandin H2 synthase 2, Prostaglandin-endoperoxide synthase 2, PTGS2