Ricombinante Anti-CFTR Anticorpo [rCFTR/7175] (A316166)

Anti-CFTR Antibody [rCFTR/7175] - BSA and Azide free

Recombinant mouse monoclonal [rCFTR/7175] antibody to CFTR.

Recognizes a protein of 165-170kDa, identified as cystic fibrosis transmembrane conductance regulator (CFTR). CFTR is composed of two membrane-spanning domains (MSD), two nucleotide-binding domains (NBD), and an R domain. It is structurally similar to multidrug resistance (Mdr1) protein and both are members of the superfamily of ATP-binding cassette (ABC) transporters, also known as traffic ATPases, which are implicated in the movement of various substrates. The CFTR protein is a small conductance adenosine 3-cyclic monophosphate (cAMP)-activated chloride ion channel found in the apical membranes of epithelia within the pancreas, airway, intestine, bile duct, sweat gland, and male genital ducts. CFTR is a valuable marker of human pancreatic duct cell development and differentiation.

IHC-P

Human pancreas, kidney or placenta.

IHC: 1-2 µg/ml

Human

Recombinant fragment (around Amino Acids 550-850) of human CFTR protein. The exact sequence is proprietary.

Mouse

Monoclonal

rCFTR/7175

IgG1

Unconjugated

Protein A/G chromatography.

1 mg/ml

165-170 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline; without Sodium Azide and carrier free.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

ABC 35, ABC35, ABCC 7, ABCC7, ATP binding cassette sub family C member 7, ATP Binding Cassette Superfamily C Member 7, ATP binding cassette transporter sub family C member 7, ATP-binding cassette sub-family C member 7, cAMP dependent chloride channel, cAMP-dependent chloride channel, CF, CFTR/MRP, CFTR_HUMAN, Channel conductance controlling ATPase, Channel conductance-controlling ATPase, Cystic fibrosis transmembrane conductance regulator, Cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub family C, member 7), Cystic fibrosis transmembrane conductance regulator ATP binding cassette sub family C member 7, Cystic Fibrosis Transmembrane Regulator, dJ760C5.1, MRP 7, MRP7, TNR CFTR