Anti-CDK4 Antibody [CDK4/8351R] - BSA and Azide free
Descrizione
Recombinant rabbit monoclonal [CDK4/8351R] antibody to CDK4.
Specificità
Cyclin-dependent kinase-4 (CDK4) is a protein-serine kinase involved in the cell cycle. It is essential for the G1- to S-phase transition during the cell cycle and its expression is primarily controlled at the transcriptional level (PMID:17253961). CCND1- CDK4 axis is not only critical in glial tumor cells but also in stromal-derived cells in the surrounding tumor microenvironment that are vital to sustain tumor outgrowth (PMID:21844184). CDK4 is highly expressed in highly differentiated and dedifferentiated liposarcomas, but rarely expressed in other benign liposarcomas and other sarcomas. CDK4 and MDM2 combined to differentiate between highly differentiated liposarcoma (+), dedifferentiated liposarcoma (+) and myxoid liposarcoma, pleomorphic liposarcoma, spindle lipoma, pleomorphic lipoma and other high-grade sarcomas.
Applicazioni
IHC-P
Controllo positivo
Human urothelial carcinoma, cervical carcinoma and liposarcomas.
Diluizioni consigliate
IHC: 1-2 µg/ml
Reattività
Human
Immunogeno
Recombinant fragment corresponding to N-terminal of human CDK4 protein.
Specie ospite
Rabbit
Clonalità
Monoclonal
Clona ID
CDK4/8351R
Isotipo
IgG
Catene leggere
kappa
Coniugare
Unconjugated
Purificazione
Protein A/G chromatography.
Concentrazione
1 mg/ml
Peso molecolare
34 kDa
Forma del prodotto
Liquid
Formulazione
Supplied in 10mM Phosphate Buffered Saline; without Sodium Azide and carrier free.
Conservazione
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.