CD79 (also designated Ig chains, designated CD79B or B29. The B cell antigen receptor complex (BCR) is formed by the association of CD79 with a membrane immunoglobulin, such as IgM or IgD. The membrane immunoglobulins IgM and IgD achieve surface expression and antigen presentation function in response to CD79 association. The cytoplasmic tails of both CD79A and CD79B contain an ITAM (immuno-receptor tyrosine-based activation) motif, which acts to initiate the BCR signaling reactions by binding to and activating tyrosine kinases.
Applications
ELISA, IHC-P
Positive Control
Daudi or Ramos cells. Germinal center B-cells in a lymph node or tonsil.
Dilutions
ELISA: 2-4 µg/ml for coating, IHC: 1-2 µg/ml
Reactivity
Human
Immunogen
Recombinant fragment of human CD79b protein. The exact sequence is proprietary.
Host
Mouse
Clonality
Monoclonal
Clone ID
CD79b/4960
Isotype
IgG1
Light Chains
kappa
Conjugate
Unconjugated
Purification
Protein A/G chromatography.
Concentration
200 µg/ml
Molecular Weight
39 kDa
Product Form
Liquid
Formulation
Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Synonyms
B-cell antigen receptor complex-associated protein beta chain, B-cell-specific glycoprotein B29, B29, Ig-beta, IGB, Immunoglobulin-associated B29 protein
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