Anti-CD70 Anticorpo [FR70] (PE) (A280488)

$515

Anticorpo monoclonale [FR70] di ratto contro CD70 (PE) per Flow Cytometry.

Spese di spedizione
Tempi di consegna
4-6 Giorni lavorativi
Telefono
+1 (314) 370-6046
Lun - Ven, 8:00 - 16:00 AST
E-mail
orders@antibodies.com
Nome
Anti-CD70 Antibody [FR70] (PE)
Descrizione
Rat monoclonal [FR70] antibody to CD70 (PE).
Specificità
This antibody recognises mouse CD70, a ~30-33 kDa single pass type II transmembrane glycoprotein belonging to the TNF superfamily. CD70 is not expressed on resting T cells and B cells but expression is induced on activation. Interaction of CD70 with its ligand CD27 is reported to play an important role in T cell co-stimulation and the regulation of T-dependant B cell activation and antibody production. Rat anti Mouse CD70 antibody, clone FR70 blocks functionality of CD70 and has been used to block the interactions between CD27 and CD70 (Oshima et al.).
Applicazioni
Flow Cytometry
Diluizioni consigliate
Flow Cytometry: Neat, Use 10µl of the suggested working dilution to label 106 cells in 100µl. The Fc region of monoclonal antibodies may bind to cells expressing low affinity Fc receptors. This may be reduced by using SeroBlock FcR (BUF041A/BUF041B).
Reattività
Mouse
Immunogeno
A20 mouse B cell lymphoma cell line.
Specie ospite
Rat
Clonalità
Monoclonal
Clona ID
FR70
Isotipo
IgG2b
Coniugare

PE

Excitation: 565nm, Emission: 578nm

Purificazione
Protein G affinity chromatography of tissue culture supernatant.
Concentrazione
Reconstitution dependent.
Forma del prodotto
Lyophilized
Ricostituzione
Reconstitute with 1 ml of distilled water. Care should be taken during reconstitution as the protein may appear as a film at the bottom of the vial. Gently mix after reconstitution.
Formulazione
Supplied in Phosphate Buffered Saline with 1% BSA, 5% Sucrose, and 0.09% Sodium Azide.
Conservazione
Lyophilized: Store at 4°C. Reconstituted: Store undiluted at 4°C. Do not freeze! This product is photosensitive and should be protected from light. Should this product contain a precipitate we recommend microcentrifugation before use.
Note generali
Rat anti Mouse CD70 antibody, clone FR70 recognizes mouse CD70, a ~30-33 kDa single pass type II transmembrane glycoprotein belonging to the TNF superfamily. CD70 is not expressed on resting T cells and B cells but expression is induced on activation. Interaction of CD70 with its ligand CD27 is reported to play an important role in T cell co-stimulation and the regulation of T-dependant B cell activation and antibody production (Nolte et al. 2009).Rat anti Mouse CD70 antibody, clone FR70 blocks functionality of CD70 and has been used to block the interactions between CD27 and CD70 (Oshima et al.).
Sinonimi
CD 27L, CD 70, CD27 L, CD27 LG, CD27 ligand, CD27-L, CD27L, CD27LG, CD70 antigen, CD70 molecule, CD70_HUMAN, Ki 24 antigen, Ki24 antigen, Surface antigen CD70, TNFSF 7, TNFSF7, Tumor necrosis factor (ligand) superfamily, member 7, Tumor necrosis factor ligand superfamily member 7
Dichiarazione di non responsabilità
Questo prodotto è solo per uso di ricerca. Non è inteso per uso diagnostico o terapeutico.

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