Anti-CD62L Anticorpo [FMC46] (FITC) (A280476)

$145

Anticorpo monoclonale [FMC46] di topo contro CD62L (FITC) per Flow Cytometry.

Alternative Formats and ConjugatesAlternative Formats

Spese di spedizione
Tempi di consegna
4-6 Giorni lavorativi
Telefono
+1 (314) 370-6046
Lun - Ven, 8:00 - 16:00 AST
E-mail
orders@antibodies.com
Nome
Anti-CD62L Antibody [FMC46] (FITC)
Descrizione
Mouse monoclonal [FMC46] antibody to CD62L (FITC).
Specificità
This antibody recognises human CD62L, also known a L-selectin, a 74-95 kDa member of the selectin family of adhesion receptors, which acts as a ligand for both CD62P (P-selectin) and CD62E (E-selectin). Human CD62L is constitutively expressed on most leucocytes including monocytes, granulocytes, lymphocytes, NK cells, bone marrow myeloid progenitor cells and on a subset of thymocytes.CD62L plays an important role in leucocyte tethering and rolling on the endothelial cell surface and for the homing of naïve lymphocytes to lymph nodes and Peyers patches via HEV. Neutrophils require a constant supply of this molecule on the cell surface for migration into peripheral tissues and adhesion to activated endothelium at sites of inflammation, where CD62L is rapidly shed as soluble L-selectin, but surface expression still remains.The expression of CD62L is down regulated on lymphocytes and neutrophils by PMA stimulation.
Applicazioni
Flow Cytometry
Diluizioni consigliate
Flow Cytometry: 1:25 - Neat Pack Size: 0.1 mg 1:100 Pack Size: 25 µg, Use 10µl of the suggested working dilution to label 106 cells or 100µl whole blood
Reattività
Human, Bovine, Cynomolgus monkey, Rhesus Monkey, Dog
Immunogeno
PHA stimulated lymphoblasts.
Specie ospite
Mouse
Clonalità
Monoclonal
Clona ID
FMC46
Isotipo
IgG2b
Coniugare

FITC

Excitation: 490nm, Emission: 525nm

Purificazione
Protein G affinity chromatography of tissue culture supernatant.
Concentrazione
100 µg/ml
Forma del prodotto
Liquid
Formulazione
Supplied in Phosphate Buffered Saline with 1% BSA and 0.09% Sodium Azide.
Conservazione
Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended. This product is photosensitive and should be protected from light.
Note generali
Mouse anti Human CD62L antibody, clone FMC46 recognizes human CD62L, also known a L-selectin, a 74-95 kDa member of the selectin family of adhesion receptors, which acts as a ligand for both CD62P (P-selectin) and CD62E (E-selectin). Human CD62L is constitutively expressed on most leucocytes including monocytes, granulocytes, lymphocytes, NK cells, bone marrow myeloid progenitor cells and on a subset of thymocytes.CD62L plays an important role in leucocyte tethering and rolling on the endothelial cell surface and for the homing of naïve lymphocytes to lymph nodes and Peyers patches via HEV. Neutrophils require a constant supply of this molecule on the cell surface for migration into peripheral tissues and adhesion to activated endothelium at sites of inflammation, where CD62L is rapidly shed as soluble L-selectin, but surface expression still remains.The expression of CD62L is down regulated on lymphocytes and neutrophils by PMA stimulation.
Sinonimi
A.11 , AI528707, CD62 antigen ligand , CD62 antigen-like family member L, gp90 MEL , gp90-MEL, hLHRc, IgA nephropathy, susceptibility to, included , L Selectin , L-selectin, LAM-1, LAM1 , LECAM1 , Leu8, Leukocyte adhesion molecule 1 , Leukocyte surface antigen Leu-8, Leukocyte surface antigen Leu8 , Leukocyte-endothelial cell adhesion molecule 1 , LNHR, LSEL, Ly-22 , Ly-m22 , Lyam-1, LYAM1 , LYAM1_HUMAN, Lymph node homing receptor , Lymphocyte adhesion molecule 1, Lymphocyte antigen 22 , Lymphocyte surface MEL-14 antigen , MEL-14, Pln homing receptor, PLNHR , Selectin L , Selectin, lymphocyte , SELL, TQ1
Dichiarazione di non responsabilità
Questo prodotto è solo per uso di ricerca. Non è inteso per uso diagnostico o terapeutico.

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