Anti-CD46 Anticorpo [MEM-258] (PE) (A281138)

Anti-CD46 Antibody [MEM-258] (PE)

Mouse monoclonal [MEM-258] antibody to CD46 (PE).

This antibody recognises the human CD46 cell surface antigen, also known as membrane co-factor protein (MCP), Trophoblast leukocyte common antigen or TLX. CD46 is a 392 amino acid (including a 34 aa signal peptide) ~43-60 kDa single pass type 1 transmembrane glysoprotein expressed by all cell types with the exception of erythrocytes.CD46 functions as areceptor for complement and inhibitor of complement activation, limiting the formation and activity of C3 convertases. CD46 is expressed by all nucleated cells, often as multiple isoforms on the same cells. The molecule is also expressed by sperm and may be important in the process of fertilisation.

Flow Cytometry

Flow Cytometry: Neat, Use 10µl of the suggested working dilution to label 10⁶ or 100µl whole blood

Human

HPB-ALL cell line.

Mouse

Monoclonal

MEM-258

IgG1

PE

Excitation: 565nm, Emission: 578nm

Reconstitution dependent.

Lyophilized

Pack Size of 25 Tests/0.25ml: Reconstitute with 0.25 ml of distilled water. Pack Size of 100 Tests: Reconstitute with 1 ml of distilled water

Supplied in Phosphate Buffered Saline with 1% BSA and 0.09% Sodium Azide.

Store undiluted at 4°C. Do not freeze! This product is photosensitive and should be protected from light. Should this product contain a precipitate we recommend microcentrifugation before use.

Mouse anti Human CD46 antibody, clone MEM-258 recognizes the human CD46 cell surface antigen, also known as membrane co-factor protein (MCP), Trophoblast leukocyte common antigen or TLX. CD46 is a 392 amino acid (including a 34 aa signal peptide) ~43-60 kDa single pass type 1 transmembrane glysoprotein expressed by all cell types with the exception of erythrocytes.CD46 functions as areceptor for complement and inhibitor of complement activation, limiting the formation and activity of C3 convertases. CD46 is expressed by all nucleated cells, often as multiple isoforms (Seya et al. 1993) on the same cells. The molecule is also expressed by sperm and may be important in the process of fertilisation (Carver-Ward et al. 1996).

AHUS2, Antigen defined by monoclonal, Antigen identified by monoclonal, CD46 antigen, CD46 antigen complement regulatory protein, CD46 molecule, CD46 molecule complement regulatory protein, Complement membrane cofactor protein, MCP, MCP_HUMAN, Measles virus receptor, Membrane cofactor protein, membrane cofactor protein (CD46, trophoblast-lymphocyte cross-reactive antigen), MGC26544, MIC10, TLX, TRA2.10, Trophoblast leucocyte common antigen, Trophoblast leukocyte common antigen, Trophoblast lymphocyte cross reactive antigen

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