Anti-CD43 Antibody [MT1] (A115613)

Anti-CD43 Antibody [MT1]

Mouse monoclonal [MT1] antbody to CD43.

This antibody binds a 95-115 kD highly sialated glycoprotein. It is used to identify B cell lines, myeloma cells, and may be used in the diagnosis of chronic lymphocytic leukemias (CLL), as an alternative to CD5. The antigen detected by MT1 is the only marker expressed on neoplasms of the very early precursor cells. In immunohistochemistry it reacts with T cells, macrophages, myeloid cells and B cells (weak). It is used for the typing of lymphomas in paraffin sections. CD43 may function as an adhesion molecule via interaction with CD54 although this has not been definitely established. It may also inhibit leucocyte interactions with other cells. The antigen is involved in the activation of T-cells, B cells, NK cells and monocytes. The membrane proximal portion of the cytoplasmic domain mediates an association with the cytoskeleton.

IHC-Fr, IHC-P, WB

Human

Human monocytes isolated by centrifµgal elutriation.

Mouse

Monoclonal

MT1

1 mg/ml

Liquid

Supplied in Phosphate Buffered Saline with 0.09% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze/thaw cycles.

Galactoglycoprotein, GALGP, GPL115, Leukocyte sialoglycoprotein, Leukosialin, Sialophorin, SPN