Anti-CD41 Anticorpo [MWReg30] (PE) (A281299)

Anti-CD41 Antibody [MWReg30] (PE)

Rat monoclonal [MWReg30] antibody to CD41 (PE).

This antibody recognises the mouse integrin alpha IIb subunit CD41. CD41 is a ~125 kDa single pass type 1 transmembrane glycoprotein expressed by platelets, megakaryocytes , mast cells , and hematopoietic progenitors. CD41 forms a heterodimer with CD61.The CD41/CD61 complex is important for platelet adhesion and aggregation acting as a receptor for many extracellular matrix proteins including fibronectin, thrombospondin and vitronectin. Rat anti mouse CD41, clone MWReg30 has been reported to inhibit PMA induced aggregation in vitro and to induce hypothermia in vivo.

Flow Cytometry

Flow Cytometry: Neat, Use 10µl of the suggested working dilution to label 10⁶ cells in 100µl. The Fc region of monoclonal antibodies may bind to cells expressing low affinity Fc receptors. This may be reduced by using SeroBlock FcR (BUF041A/BUF041B).

Mouse

Purified murine platelets.

Rat

Monoclonal

MWReg30

IgG1

Protein G affinity chromatography of tissue culture supernatant.

Reconstitution dependent.

Lyophilized

Reconstitute with 1 ml of distilled water.

Supplied in Phosphate Buffered Saline with 1% BSA, 5% Sucrose, and 0.09% Sodium Azide.

Lyophilized: Store at 4°C. Reconstituted: Store undiluted at 4°C. Do not freeze! This product is photosensitive and should be protected from light. Should this product contain a precipitate we recommend microcentrifugation before use.

Rat anti Mouse CD41 antibody, clone MWReg30 recognizes the mouse integrin alpha IIb subunit CD41. CD41 is a ~125 kDa single pass type 1 transmembrane glycoprotein expressed by platelets, megakaryocytes (Zhang et al. 2007), mast cells (Berlanga et al. 2005), and hematopoietic progenitors (Mitjavila-Garcia et al. 2002). CD41 forms a heterodimer with CD61.The CD41/CD61 complex is important for platelet adhesion and aggregation (Patel et al. 2003) acting as a receptor for many extracellular matrix proteins including fibronectin, thrombospondin and vitronectin (Weisel et al. 1992).Rat anti mouse CD41, clone MWReg30 has been reported to inhibit PMA induced aggregation in vitro and to induce hypothermia in vivo (Nieswandt et al. 1999).

antigen CD41, BDPLT16, BDPLT2, CD41B, form 2, GP2B, GPalpha IIb, GPIIb, GT, GTA, HPA3, Integrin alpha 2b, Integrin alpha IIb, Integrin alpha-IIb light chain, Integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41), ITA2B_HUMAN, Itga2b, ITGAB, platelet fibrinogen receptor, alpha subunit, platelet glycoprotein IIb of IIb/IIIa complex, Platelet membrane glycoprotein IIb, platelet specific antigen BAK, PPP1R93

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