Anti-CD40 Anticorpo [FGK45.5] (A251036)

Anti-CD40 Antibody [FGK45.5]

Rat monoclonal [FGK45.5] antibody to CD40.

Upon binding to its ligand CD154, CD40 acts as a costimulatory molecule for the activation of B cells, dendritic cells, monocytes, and other APCs. CD40 plays roles in B cell activation, differentiation, proliferation and Ig isotype switching as well as dendritic cell maturation. FGK4.5 can be used for blocking of CD40/CD154 interaction and forin vitroandin vivoactivation of CD40 expressing APCs. This MAb is shown to indirectly activate natural killer (NK) cells, producing significant antitumor and anti-metastatic effects. Effective in boosting immune responses against infectious agents and can potentially be used to treat chronic autoimmune inflammatory processes.

Functional Studies, Flow Cytometry, IF

Flow Cytometry: 0.5-1 µg/million cells, IF: 1-2 µg/ml

Mouse

This antibody does not cross react with Human.

Recombinant mouse CD40 fusion protein.

Rat

Monoclonal

FGK45.5

IgG2a

kappa

Unconjugated

200 µg/ml

48 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-CD40 Antibody [FGK45.5] - BSA and Azide free (A254215).

AI326936, B cell associated molecule , B cell associated molecule CD40, B cell surface antigen CD40 , B cell-associated molecule, B-cell surface antigen CD40, Bp50, CD 40 , CD40 antigen , CD40 antigen (TNF receptor superfamily member 5), CD40 molecule , CD40 molecule TNF receptor superfamily member 5, CD40 molecule, TNF receptor superfamily member 5, CD40 protein , CD40 type II isoform , CD40L receptor , CDw40, GP39 , HIGM1, IGM , IMD3, MGC9013, Nerve growth factor receptor related B lymphocyte activation molecule , NFRSF5 , OTTHUMP00000031699, OTTHUMP00000031700 , p50, T BAM , T-BAM, TBAM, TNF receptor superfamily member 5, TNFRSF5, TNR5_HUMAN, TRAP, Tumor necrosis factor receptor superfamily , member 5, Tumor necrosis factor receptor superfamily member 5, Tumor necrosis factor receptor superfamily member 5 precursor , Tumor necrosis factor receptor superfamily, member 5, isoform CRA_a