Anti-CD3G Antibody [CD3G/8794] - BSA and Azide free (A316086)

Anti-CD3G Antibody [CD3G/8794] - BSA and Azide free

Mouse monoclonal [CD3G/8794] antibody to CD3G.

The T cell antigen receptor (TCR) recognizes foreign antigens and translates such recognition events into intracellular signals that elicit a change in the cell from a dormant to an activated state. Much of this signaling process can be attributed to a multisubunit complex of proteins that associates directly with the TCR. This complex has been designated CD3 (cluster of differentiation 3). It is composed of five invariant polypeptide chains that associate to form three dimers: a heterodimer of g and e chains (ge), a heterodimer of d and e chains (de) and a homodimer of two z chains (zz) or a heterodimer of z and h chains (zh). The z and h chains are encoded by the same gene but differ in their carboxyl-terminal ends due to an alternative splicing event. The g, e and d chains each contain a single copy of a conserved immunoreceptor tyrosinebased activation motif (ITAM). In contrast, the z chain contains three consecutive copies of the same motif. Phosphorylated ITAMs act as docking sites for protein kinases such as ZAP-70 and Syk and are also capable of regulating their kinase activity. The crystal structure of the ZAP-70 SH2 domains bound to the z chain ITAMs has been solved.

Human colon, tonsil or spleen.

IHC: 1-2 µg/ml

Human

Recombinant fragment (around Amino Acids 1-182) of human CD3G protein. The exact sequence is proprietary.

Mouse

CD3G/8794

IgG2c

kappa

Protein A/G chromatography.

1 mg/ml

18-28 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline; without Sodium Azide and carrier free.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

T-cell receptor T3 gamma chain, T-cell surface glycoprotein CD3 gamma chain, T3G