Anti-CD33 Anticorpo [SIGLEC3/3597] (A316051)

$765

Anticorpo monoclonale [SIGLEC3/3597] di topo contro CD33 per IHC-P.

Alternative Formats and ConjugatesAlternative Formats

Spese di spedizione
Tempi di consegna
4-6 Giorni lavorativi
Telefono
+1 (314) 370-6046
Lun - Ven, 8:00 - 16:00 AST
E-mail
orders@antibodies.com
Nome
Anti-CD33 Antibody [SIGLEC3/3597] - BSA and Azide free
Descrizione
Mouse monoclonal [SIGLEC3/3597] antibody to CD33.
Specificità
Recognizes a 67kDa glycoprotein, which is identified as CD33. It is a transmembrane protein of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. It belongs to the immunoreceptor tyrosine-based inhibitory motif (ITIM)-containing molecules able of recruiting protein tyrosine phosphatases SHP-1 and SHP-2 to signal assemblies; these ITIMs are also used for ubiquitin-mediated removal of the receptor from the cell surface. CD33 is expressed on cells of myelomonocytic lineage, binds sialic acid residues in N- and O-glycans on cell surfaces, and is a therapeutic target for acute myeloid leukemia. CD33 is expressed on myeloid progenitors, monocytes, granulocytes, dendritic cells and mast cells. It is absent on platelets, lymphocytes, erythrocytes and hematopoietic stem cells.
Applicazioni
IHC-P
Controllo positivo
Human dendritic and mast cells. Human lymph nodes and tonsils.
Diluizioni consigliate
IHC: 1-2 µg/ml
Reattività
Human
Immunogeno
Recombinant fragment (around Amino Acids a1-250) of human CD33 protein. The exact sequence is proprietary.
Specie ospite
Mouse
Clonalità
Monoclonal
Clona ID
SIGLEC3/3597
Isotipo
IgG2b
Catene leggere
kappa
Coniugare

Unconjugated

Purificazione
Protein A/G chromatography.
Concentrazione
1 mg/ml
Peso molecolare
67 kDa
Forma del prodotto
Liquid
Formulazione
Supplied in 10mM Phosphate Buffered Saline; without Sodium Azide and carrier free.
Conservazione
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Sinonimi
CD 33, CD33 antigen, CD33 antigen (gp67), CD33 molecule, CD33_HUMAN, FLJ00391, gp67, My9, Myeloid cell surface antigen CD33, Myeloid cell surface antigen CD33 precursor, Myeloid differentiation antigen CD33, p67, Sialic acid binding Ig like lectin 3, Sialic acid binding immunoglobulin like lectin 3, Sialic acid-binding Ig-like lectin 3, SIGLEC 3, Siglec-3, SIGLEC3
Dichiarazione di non responsabilità
Questo prodotto è solo per uso di ricerca. Non è inteso per uso diagnostico o terapeutico.

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