Anti-CD3 epsilon Antibody [PC3/188A] - BSA and Azide free (A253673)

Anti-CD3 epsilon Antibody [PC3/188A] - BSA and Azide free

Mouse monoclonal [PC3/188A] antibody to CD3 epsilon.

This antibody recognizes the epsilon-chain of CD3, which consists of five different polypeptide chains (designated as gamma, delta, epsilon, zeta, and eta) with MW ranging from 16-28kDa. The CD3 complex is closely associated at the lymphocyte cell surface with the T cell antigen receptor (TCR). Reportedly, CD3 complex is involved in signal transduction to the T cell interior following antigen recognition. The CD3 antigen is first detectable in early thymocytes and probably represents one of the earliest signs of commitment to the T cell lineage. In cortical thymocytes, CD3 is predominantly intra-cytoplasmic. However, in medullary thymocytes, it appears on the T cell surface. CD3 antigen is a highly specific marker for T cells, and is present in majority of T cell neoplasms.

Flow Cytometry, IF, WB

Flow Cytometry: 1-2 µg/million cells, IF: 1-2 µg/ml, WB: 1-2 µg/ml

Human, Rat, Guinea Pig, Rabbit, Porcine, Horse, Bovine, Chicken

Synthetic peptide corresponding to amino acids 156-168 of the cytoplasmic domain of human CD3 epsilon chain.

Mouse

Monoclonal

PC3/188A

IgG1

Protein A/G chromatography.

1 mg/ml

20 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline; without Sodium Azide and carrier free.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

This monoclonal antibody is also available in a different formulation with BSA and Sodium Azide - Anti-CD3 epsilon Antibody [PC3/188A] (A250493).

CD3e, T-cell surface antigen T3/Leu-4 epsilon chain, T-cell surface glycoprotein CD3 epsilon chain, T3E