Anti-CD276 Anticorpo [B7H3/4313] (A316027)

$765

Anticorpo monoclonale [B7H3/4313] di topo contro CD276 per IHC-P.

Alternative Formats and ConjugatesAlternative Formats

Spese di spedizione
Tempi di consegna
4-6 Giorni lavorativi
Telefono
+1 (314) 370-6046
Lun - Ven, 8:00 - 16:00 AST
E-mail
orders@antibodies.com
Nome
Anti-CD276 Antibody [B7H3/4313] - BSA and Azide free
Descrizione
Mouse monoclonal [B7H3/4313] antibody to CD276.
Specificità
T cell activation and immune function are regulated by the innate immune system through positive and negative costimulatory molecules. One such molecule, B7-H3 (B7-homolog 3, also designated B7RP-2) belongs to the B7 immunoglobulin superfamily. Soluble B7-H3 binds a putative receptor on activated T-cells that is distinct from CD28, CTLA-4, ICOS and PD-1. Widely expressed on nonlymphoid tissues, B7-H3 costimulates proliferation of both CD4+ and CD8+ T cells. The ability of B7-H3 to stimulate Th1 and cytotoxic-T cell responses suggest that it may have antitumor activity. B7-H3 interactions may play a role in regulating cell-mediated immune responses against cancer, implicating B7-H3 as a potential therapeutic tool.
Applicazioni
IHC-P
Controllo positivo
Human tonsil, placenta, hepatocellular carcinoma or lung carcinoma.
Diluizioni consigliate
IHC: 1-2 µg/ml
Reattività
Human
Immunogeno
Recombinant fragment (around Amino Acids 100-300) of human CD276 protein. The exact sequence is proprietary.
Specie ospite
Mouse
Clonalità
Monoclonal
Clona ID
B7H3/4313
Isotipo
IgG1
Catene leggere
kappa
Coniugare

Unconjugated

Purificazione
Protein A/G chromatography.
Concentrazione
1 mg/ml
Peso molecolare
B7-H3 isoforms: 57 kDa / 34 kDa / 53 kDa / 57 kDa / glycosylated B7-H3: 90-110 kDa
Forma del prodotto
Liquid
Formulazione
Supplied in 10mM Phosphate Buffered Saline; without Sodium Azide and carrier free.
Conservazione
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Sinonimi
4Ig B7 H3, 4Ig-B7-H3, AU016588, B7 H3, B7 homolog 3, B7-H3, B7H3, B7RP-2, CD276 antigen, CD276 molecule, CD276_HUMAN, CD_antigen=CD276, Costimulatory molecule, Flags: Precursor, PSEC0249, UNQ309/PRO352
Dichiarazione di non responsabilità
Questo prodotto è solo per uso di ricerca. Non è inteso per uso diagnostico o terapeutico.

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