Anti-CD21 Antibody [rCR2/6964] (A314620)

Anti-CD21 Antibody [rCR2/6964]

Mouse monoclonal [rCR2/6964] antibody to CD21.

Recognizes a protein of 140kDa, which is identified as the complement receptor 2 (CR2) or CD21. This protein is expressed strongly on mature B cells, follicular dendritic cells and weakly on immature thymocytes and T lymphocytes. In B-cell ontogeny, CD21 appears after the pre-B-stage, is maintained during peripheral B-cell development and is lost upon terminal differentiation into plasma cells. CD21 expression is also gradually lost after stimulation of B cells in vitro. CD21 functions as receptor for C3d, C3dg and iC3b Complement components, for EBV and for IFNalpha. CD21 binds to CD23 and associates with CD19, CD81 and Leu13 to form a large signal-transduction complex involved in B cell activation.

MOLT4, Raji or WEHI-231 cells. Human tonsil.

IHC: 1-2 µg/ml

Human

Recombinant fragment (around Amino Acids 900-1033) of human CR2 (CD21) protein. The exact sequence is proprietary.

Mouse

Monoclonal

rCR2/6964

kappa

Protein A/G chromatography.

200 µg/ml

140 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

C3DR, Complement C3d receptor, Complement receptor type 2, Cr2, EBV receptor, Epstein-Barr virus receptor