Recombinant Anti-CD21 Antibody [rCR2/1952] (A248262)

Anti-CD21 Antibody [rCR2/1952]

Recombinant mouse monoclonal [rCR2/1952] antibody to CD21.

This antibody recognizes a protein of 140kDa, which is identified as the complement receptor 2(CR2)/CD21. This protein is expressed strongly on mature B cells, follicular dendritic cells and weakly on immature thymocytes and T lymphocytes. In B-cell ontogeny, CD21 appears after the pre-B-stage, is maintained during peripheral B-cell development and is lost upon terminal differentiation into plasma cells. CD21 expression is also gradually lost after stimulation of B cells in vitro.CD21 functions as receptor for C3d, C3dg and iC3b Complement components, for EBV and for IFNalpha.CD21 binds to CD23 and associates with CD19, CD81 and Leu13 to form a large signal-transduction complex involved in B cell activation.

IHC-P: 1-2 µg/ml

Human

Recombinant fragment, around amino acids 44-196, of human CD21, protein. The exact sequence is proprietary.

Mouse

Monoclonal

rCR2/1952

IgG1

kappa

Protein A/G chromatography.

200 µg/ml

140 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-CD21 Antibody [rCR2/1952] - BSA and Azide free (A251444).

C3DR, Complement C3d receptor, Complement receptor type 2, Cr2, EBV receptor, Epstein-Barr virus receptor