The Mouse monoclonal antibody recognizes CD1b, a 44kDa type I glycoprotein associated with beta2-microglobulin (Workshop IV; Code T015). It is expressed on dendritic cells, Langerhans cells, thymocytes, and T acute lymphoblastic leukemia cells. The CD1 multigene family encodes five forms of the CD1 T-cell surface glycoprotein in human, designated CD1A, 1B, 1C, 1D and 1E. CD1, a type 1 membrane protein, has structural similarity to the MHC class I antigen and has been shown to present lipid antigens for recognition by T lymphocytes. Constitutive endocytosis of CD1B molecules and the differential sorting of MHC class II from lysosomes separate peptide- and lipid antigen-presenting molecules during dendritic cell maturation. CD1B is also expressed in interdigitating cells.

Applicazioni

Flow Cytometry, IF, Functional Studies

Diluizioni consigliate

Flow Cytometry: 1-2 µg/million cells, IF: 1-2 µg/ml

Reattività

Human

Immunogeno

Stimulated human leukocytes.

Specie ospite

Mouse

Clonalità

Monoclonal

Clona ID

100-1A5

Isotipo

IgM

Catene leggere

kappa

Coniugare

Unconjugated

Purificazione

Protein A/G chromatography.

Concentrazione

1 mg/ml

Forma del prodotto

Liquid

Formulazione

Supplied in 10mM Phosphate Buffered Saline; without Sodium Azide and carrier free.

Conservazione

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Note generali

This monoclonal antibody is also available in a different formulation with BSA and Sodium Azide - Anti-CD1b Antibody [100-1A5] (A251077).

Sinonimi

A1 domain, CD1, CD1A, CD1b antigen, CD1B antigen b polypeptide, CD1b molecule, CD1B_HUMAN, Cortical thymocyte antigen CD1A, Cortical thymocyte antigen CD1B, Differentiation antigen CD1 alpha 3, hTa1 thymocyte antigen, Ly38, Ly38; T cell surface glycoprotein CD1a, MGC125990, MGC125991, R1, T-cell surface glycoprotein CD1b, T6/Leu6, Thymocite antigen CD1B

Controlli isotipo

Mouse IgM [PRF-03] (A86761)

Secondari adatti

Dichiarazione di non responsabilità

Questo prodotto è solo per uso di ricerca. Non è inteso per uso diagnostico o terapeutico.

Immagini (1)

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Figure 1: SDS-PAGE - Anti-CD1b Antibody [100-1A5] - BSA and Azide free (A254354)

SDS-PAGE analysis of Anti-CD1b Antibody [100-1A5] under non-reduced and reduced conditions; showing intact IgG and intact heavy and light chains, respectively. SDS-PAGE analysis confirms the integrity and purity of the antibody.