Anti-CD1a Antibody [C1A/2777] (A314606)

Anti-CD1a Antibody [C1A/2777]

Mouse monoclonal [C1A/2777] antibody to CD1a.

At least five CD1 genes (CD1a, b, c, d, and e) are identified. CD1 proteins have been demonstrated to restrict T cell response to non-peptide lipid and glycolipid antigens and play a role in non-classical antigen presentation. CD1a is a non-polymorphic MHC Class 1 related cell surface glycoprotein, expressed in association with Beta-2 microglobulin. Anti-CD1a labels Langerhans cell histiocytosis (Histiocytosis X), extranodal histiocytic sarcoma, a subset of T-lymphoblastic lymphoma/leukemia, and interdigitating dendritic cell sarcoma of the lymph node. When combined with antibodies against TTF-1 and CD5, anti-CD1a is useful in distinguishing between pulmonary and thymic neoplasms since CD1a is consistently expressed in thymic lymphocytes in both typical and atypical thymomas, but only focally in 1/6 of thymic carcinomas and not in lymphocytes in pulmonary neoplasms. Anti-CD1a is reported to be a new marker for perivascular epithelial cell tumor (PEComa).

MOLT-4 cells. Paracortex in a tonsil or a reactive lymph node.

IHC: 1-2 µg/ml

Human

Recombinant fragment (around Amino Acids 1-200) of human CD1a protein. The exact sequence is proprietary.

Mouse

Monoclonal

C1A/2777

kappa

Protein A/G chromatography.

200 µg/ml

49 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

hTa1 thymocyte antigen, T-cell surface antigen T6/Leu-6, T-cell surface glycoprotein CD1a