This antibody recognises human SIRP gamma, a 55 kDa signal regulatory protein which is a member of the immunoglobulin gene superfamily. SIRP gamma, also known as CD172g, is expressed on most T lymphocytes and a subset of B-cells but is absent on myeloid cells. CD172g has a truncated cytoplasmic tail, which is similar to SIRP beta, but unlike SIRP beta CD172g does not require DAP12 for expression at the cell surface. CD172g, like SIRP alpha, binds to CD47 inducing apoptosis. It is also involved in the negative regulation of receptor tyrosine kinase-coupled signalling.

Applicazioni

IP, Flow Cytometry

Diluizioni consigliate

Flow Cytometry: 1:50 - 1:200, Use 10µl of the suggested working dilution to label 1x10⁶ cells in 100µl.

Reattività

Human

Immunogeno

Purified recombinant SIRP gamma.CD4.

Specie ospite

Mouse

Clonalità

Monoclonal

Clona ID

OX119

Isotipo

IgG1

Coniugare

Unconjugated

Purificazione

Protein G affinity chromatography of tissue culture supernatant.

Concentrazione

1 mg/ml

Forma del prodotto

Liquid

Formulazione

Supplied in Phosphate Buffered Saline with 0.09% Sodium Azide.

Conservazione

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Note generali

Mouse anti Human CD172g antibody, clone OX119 recognizes human SIRP gamma, a 55 kDa signal regulatory protein which is a member of the immunoglobulin gene superfamily. SIRP gamma, also known as CD172g, is expressed on most T lymphocytes and a subset of B-cells but is absent on myeloid cells. CD172g has a truncated cytoplasmic tail, which is similar to SIRP beta, but unlike SIRP beta CD172g does not require DAP12 for expression at the cell surface. CD172g, like SIRP alpha, binds to CD47 inducing apoptosis. It is also involved in the negative regulation of receptor tyrosine kinase-coupled signalling.

Sinonimi

bA77C3.1, CD172 antigen like family member B, CD172 antigen-like family member B, CD172g, CD172g antigen, FLJ42230, RP11-77C3.2, Signal regulatory protein beta 2, Signal regulatory protein gamma, Signal-regulatory protein beta-2, Signal-regulatory protein gamma, SIRP B2, SIRP beta 2, SIRP gamma, SIRP-b2, SIRP-beta-2, SIRP-gamma, SIRPB2, SIRPG, SIRPgamma, SIRPG_HUMAN

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Secondari adatti

Dichiarazione di non responsabilità

Questo prodotto è solo per uso di ricerca. Non è inteso per uso diagnostico o terapeutico.