This antibody recognises human neprilysin, also known as CD10, atriopeptidase, enkephalinase, neutral endopeptidase 24.11, skin fibroblast elastase or common acute lymphocytic leukemia antigen (CALLA). CD10 is a 749 aminoacid, ~100 kDa single pass type II transmembrane glycoprotein expressed by acute lymphoblastic leukaemia cells and by peripheral blood granulocytes.Defects in the MME gene encoding CD10 can lead to the development of the peripheral nervous system disorder, Charcot-Marie-Tooth disease 2T (CMY2T), an axonal form of Marie-Charcot-Tooth disease characterized by either dominantly inherited primary peripheral demyelinating neuropathies, designated CMT1, or primary peripheral axonal neuropathies showing axonal degeneration in the absence of any obvious myelin alteration (CMT2).

Applicazioni

Flow Cytometry, WB, IHC-Fr, IP

Diluizioni consigliate

Flow Cytometry: 1:100 for 0.1 mg, 1:10 for 0.2 mg - 1:200 for 0.1 mg, 1:25 for 0.2 mg, Use 10µl of the suggested working dilution to label 10⁶ cells in 100µl

Reattività

Human

Immunogeno

Partially purified cell membrane antigens from fresh leukemia cells.

Specie ospite

Mouse

Clonalità

Monoclonal

Clona ID

SN5c

Isotipo

IgG1

Coniugare

Unconjugated

Purificazione

Protein A affinity chromatography of tissue culture supernatant.

Concentrazione

1 mg/ml

Forma del prodotto

Liquid

Formulazione

Supplied in Phosphate Buffered Saline.

Conservazione

Store undiluted at -20°C only. Storage in frost free freezers is not recommended. Avoid freeze-thaw cycles. Should this product contain a precipitate we recommend microcentrifugation before use.

Note generali

Mouse anti Human CD10 antibody, clone SN5c recognizes human neprilysin, also known as CD10, atriopeptidase, enkephalinase, neutral endopeptidase 24.11, skin fibroblast elastase or common acute lymphocytic leukemia antigen (CALLA). CD10 is a 749 aminoacid, ~100 kDa single pass type II transmembrane glycoprotein expressed by acute lymphoblastic leukaemia cells and by peripheral blood granulocytes.Defects in the MME gene encoding CD10 can lead to the development of the peripheral nervous system disorder, Charcot-Marie-Tooth disease 2T (CMY2T), an axonal form of Marie-Charcot-Tooth disease characterized by either dominantly inherited primary peripheral demyelinating neuropathies, designated CMT1, or primary peripheral axonal neuropathies showing axonal degeneration in the absence of any obvious myelin alteration (CMT2).

Sinonimi

Atriopeptidase, CALLA, CD10 antigen, Common acute lymphocytic leukemia antigen, DKFZp686O16152, EC 3.4.24.11, Enkephalinase, EPN, Membrane metallo endopeptidase, Membrane metallo endopeptidase (neutral endopeptidase, enkephalinase), Membrane metallo endopeptidase (neutral endopeptidase, enkephalinase, CALLA, CD10), Membrane metallo endopeptidase variant 1, Membrane metallo endopeptidase variant 2, Membrane metalloendopeptidase, Membrane metalloendopeptidase neutral endopeptidase enkephalinase, Membrane metalloendopeptidase neutral endopeptidase enkephalinase CALLA CD10, Membrane metalloendopeptidase variant 1, Membrane metalloendopeptidase variant 2, MGC126681, MGC126707, MME, NEP, Neprilysin, neprilysin-390, neprilysin-411, NEP_HUMAN, Neutral endopeptidase, Neutral endopeptidase 24.11, Neutral endopeptidase, membrane-associated, SFE, Skin fibroblast elastase

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Secondari adatti

Dichiarazione di non responsabilità

Questo prodotto è solo per uso di ricerca. Non è inteso per uso diagnostico o terapeutico.