This antibody recognises human caspase-2, a 53 kDa member of the cysteine-aspartic acid protease (caspase) family. Caspase-2 is required for the permeabilisation of the mitochondria and the resulting amplification of caspase activity, in response to cytotoxic stress. Cytotoxic stress induced proteolytic cleavage of the caspase-2 proenzyme forms an active caspase which cleaves other caspases in a cascade. This leads to the release of cytochrome c and Smac from mitochondria and the translocation of Bax from the cytoplasm to the mitochondria, leading to apoptosis. In adults, caspase-2 is expressed in the placenta, lung, kidney, pancreas and at lower levels in the heart, brain, liver and skeletal muscle.

Applicazioni

WB, IHC-P

Diluizioni consigliate

IHC-P 1: 10 µg/ml, WB: 1 µg/ml

Reattività

Human, Mouse

Immunogeno

Synthetic peptide corresponding to 6 amino acids near the N-terminus of human Caspase-2.

Specie ospite

Rabbit

Clonalità

Polyclonal

Isotipo

IgG

Coniugare

Unconjugated

Concentrazione

1 mg/ml

Forma del prodotto

Liquid

Formulazione

Supplied in Phosphate Buffered Saline with <0.1% Sodium Azide.

Conservazione

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Note generali

recognises human caspase-2, a 53 kDa member of the cysteine-aspartic acid protease (caspase) family. Caspase-2 is required for the permeabilisation of the mitochondria and the resulting amplification of caspase activity, in response to cytotoxic stress. Cytotoxic stress induced proteolytic cleavage of the caspase-2 proenzyme forms an active caspase which cleaves other caspases in a cascade. This leads to the release of cytochrome c and Smac from mitochondria and the translocation of Bax from the cytoplasm to the mitochondria, leading to apoptosis. In adults, caspase-2 is expressed in the placenta, lung, kidney, pancreas and at lower levels in the heart, brain, liver and skeletal muscle.

Sinonimi

CASP 2, CASP-2, Casp2, CASP2_HUMAN, Caspase 2, Caspase 2 apoptosis related cysteine peptidase, Caspase-2 subunit p12, Caspase2, ICH 1, ICH 1 protease, ICH 1L, ICH1, ICH1 protease, ICH1L, NEDD-2, NEDD2, Neural precursor cell expressed developmentally down-regulated protein 2, PPP1R57, Protease ICH-1, Protein phosphatase 1 regulatory subunit 57

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Secondari adatti

Dichiarazione di non responsabilità

Questo prodotto è solo per uso di ricerca. Non è inteso per uso diagnostico o terapeutico.