This antibody recognises calretinin, a ~29 kDa calcium binding protein found mostly in the central nervous system and retina. It is a cytoplasmic protein involved in the regulation of calcium concentration, which is important in the regulation of a large variety of neuronal functions, including neurotransmitter release, ionic channel permeability, enzyme activity, and gene transcription. Mice deficient in calretinin show impairment in motor coordination.Calretinin is a sensitive and specific marker for mast cells.
Applicazioni
WB, IHC-Fr
Diluizioni consigliate
IHC-Fr: 1:500, WB: 1:1,000
Reattività
Guinea Pig, Rat, Human, Mouse, Primate
Immunogeno
Purified guinea pig calretinin.
Specie ospite
Sheep
Clonalità
Polyclonal
Isotipo
IgG
Coniugare
Unconjugated
Concentrazione
Lot Specific
Peso molecolare
Approximately 29 kDa in rat cerebellum.
Forma del prodotto
Liquid
Formulazione
Supplied in TRIS Buffered Saline.
Conservazione
Store undiluted at -20°C only. Storage in frost free freezers is not recommended. Avoid freeze-thaw cycles. Should this product contain a precipitate we recommend microcentrifugation before use.
Note generali
Sheep anti calretinin antibody recognizes calretinin, a ~29 kDa calcium binding protein found mostly in the central nervous system and retina. It is a cytoplasmic protein involved in the regulation of calcium concentration, which is important in the regulation of a large variety of neuronal functions, including neurotransmitter release, ionic channel permeability, enzyme activity, and gene transcription. Mice deficient in calretinin show impairment in motor coordination.Calretinin is a sensitive and specific marker for mast cells.