Ricombinante Anti-Cadherin 16 Anticorpo [CDH16/8800R] (A314531)

Anti-Cadherin 16 Antibody [CDH16/8800R]

Recombinant rabbit monoclonal [CDH16/8800R] antibody to Cadherin 16.

This MAb recognizes a protein of 130kDa, identified as Ksp-cadherin. Cadherins form a superfamily of related glycoproteins that mediate calcium-dependent cell adhesion and transmit signals from the extracellular matrix to the cytoplasm. Cadherins have been implicated in embryogenesis, tissue morphogenesis, tissue structure maintenance, cell polarization, neoplastic invasiveness and metastasis, and membrane transport. It is suggested that Ksp-cadherin is a marker for terminal differentiation of the basolateral membranes of renal tubular epithelial cells. Within the kidney, Ksp-Cadherin is found exclusively in the basolateral membrane of renal tubular epithelial cells and collecting duct cells, and not in glomeruli, renal interstitial cells, or blood vessels.Ksp-Cadherin has been suggested to distinguish Chromophobe Renal-Cell Carcinoma from Oncocytoma.

IHC-P

Normal kidney or renal cell carcinoma.

IHC: 1-2 µg/ml

Human, Mouse, Rat

Recombinant fragment (around Amino Acids 350-550) of human CDH16 protein. The exact sequence is proprietary.

Rabbit

Monoclonal

CDH16/8800R

kappa

Unconjugated

Protein A chromatography.

200 µg/ml

130 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

CAD16_HUMAN, Cadherin 16 KSP cadherin, Cadherin kidney, Cadherin-16, CDH 16, CDH16, Kidney cadherin, Kidney specific cadherin, Kidney-specific cadherin, Ksp cadherin, Ksp-cadherin, PRO1340, UNQ695