This antibody recognises complement component 9 (C9), a 71 kDa member of the complement C6/C7/C8/C9 family present in the blood serum and synthesised by the liver and monocytes. C9 is the last component to be added during the formation of the membrane attack complex (MAC), binding the membrane associated C5b-8 complex and resulting in the circular polymerisation of 12-18 C9 molecules. This forms the hydrophilic transmembrane channel which causes cell lysis. Deficiency of C9 is associated with recurring infections by Neisseria meningitides. Mouse anti Human C9 antibody, clone 002-94.8.8 does not recognise MAC.
Applicazioni
ELISA
Reattività
Human
Immunogeno
Purified human C9.
Specie ospite
Mouse
Clonalità
Monoclonal
Clona ID
002-94.8.8
Isotipo
IgG2b
Coniugare
Unconjugated
Purificazione
Protein A affinity chromatography of ascites.
Concentrazione
1 mg/ml
Forma del prodotto
Liquid
Formulazione
Supplied in Borate Buffered Saline with 0.1% Sodium Azide.
Conservazione
Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.
Note generali
Mouse anti Human C9 antibody, clone 002-94.8.8 recognises complement component 9 (C9), a 71 kDa member of the complement C6/C7/C8/C9 family present in the blood serum and synthesised by the liver and monocytes. C9 is the last component to be added during the formation of the membrane attack complex (MAC), binding the membrane associated C5b-8 complex and resulting in the circular polymerisation of 12-18 C9 molecules. This forms the hydrophilic transmembrane channel which causes cell lysis. Deficiency of C9 is associated with recurring infections by Neisseria meningitides.Mouse anti Human C9 antibody, clone 002-94.8.8 does not recognise MAC.
