Anti-C8 Anticorpo [056B-373] (A278908)

$525

Anticorpo monoclonale [056B-373] di topo contro C8 per Flow Cytometry, ELISA, IHC-Fr e WB.

Spese di spedizione
Tempi di consegna
4-6 Giorni lavorativi
Telefono
+1 (314) 370-6046
Lun - Ven, 8:00 - 16:00 AST
E-mail
orders@antibodies.com
Nome
Anti-C8 Antibody [056B-373]
Descrizione
Mouse monoclonal [056B-373] antibody to C8.
Specificità
This antibody recognises complement component 8 (C8), a 151 kDa member of the complement C6/C7/C8/C9 family, present in serum. C8 is a terminal component of the complement system, part of both the complement membrane attack complex (MAC), and important to MAC assembly. C8 binds to the C5b-7 complex, anchored to the membrane, creating C5b-8. C5b-8 binds C9 and catalyses the polymerization of C9 molecules to form C5-b9 (MAC). C8 is thought to contain lipid binding sites, facilitating the insertion of MAC into the membrane.Defects in the alpha chain of C8 can result in complement C8 deficiency type I. Furthermore, C8 deficiencies can cause recurring bacterial infections, in particular from Neisseria meningitides.
Applicazioni
Flow Cytometry, ELISA, IHC-Fr, WB
Reattività
Human
Immunogeno
Purified human C8.
Specie ospite
Mouse
Clonalità
Monoclonal
Clona ID
056B-373
Isotipo
IgG1
Coniugare

Unconjugated

Purificazione
Protein A affinity chromatography of ascites.
Concentrazione
Lot Specific
Forma del prodotto
Liquid
Formulazione
Supplied in Borate Buffered Saline with 0.1% Sodium Azide.
Conservazione
Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.
Note generali
Mouse anti Human C8 antibody, clone 056B-373 recognizes complement component 8 (C8), a 151 kDa member of the complement C6/C7/C8/C9 family, present in serum. C8 is a terminal component of the complement system, part of both the complement membrane attack complex (MAC), and important to MAC assembly. C8 binds to the C5b-7 complex, anchored to the membrane, creating C5b-8. C5b-8 binds C9 and catalyses the polymerization of C9 molecules to form C5-b9 (MAC). C8 is thought to contain lipid binding sites, facilitating the insertion of MAC into the membrane.Defects in the alpha chain of C8 can result in complement C8 deficiency type I. Furthermore, C8 deficiencies can cause recurring bacterial infections, in particular from Neisseria meningitides.
Sinonimi
C8A, C8B, C8G, Complement component 8 subunit alpha, Complement component 8 subunit beta, complement component 8, alpha polypeptide, complement component 8, beta polypeptide, complement component 8, gamma polypeptide, Complement component C8 alpha chain, Complement component C8 beta chain, Complement component C8 gamma chain, MGC142186, MGC163447
Dichiarazione di non responsabilità
Questo prodotto è solo per uso di ricerca. Non è inteso per uso diagnostico o terapeutico.
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