This antibody recognises complement component 7 (C7), a 110 kDa glycoprotein present in the blood serum. The factor I domain of C7 binds the C terminus of the C5 alpha-chain, acting as a membrane anchor. This enables the assembly of the complement membrane attack complex (MAC) and consequent complement lytic activity. C7 deficiency is associated with increased susceptibility to recurrent infections, in particular by Neisseria meningitides. Mouse anti Human C7 antibody, clone 030-113.7.5.4 does not recognie membrane bound complement membrane attack complex. Mouse anti Human C7 antibody, clone 030-113.7.5.4 inhibits lysis of sensitised sheep erythrocytes.Removal of Sodium Azide is recommended prior to use in functional assays.

Applicazioni

ELISA, WB, Functional Assays

Reattività

Human

Immunogeno

Purified human C7.

Specie ospite

Mouse

Clonalità

Monoclonal

Clona ID

030-113.7.5.4

Isotipo

IgG1

Coniugare

Unconjugated

Purificazione

Protein A affinity chromatography of ascites.

Concentrazione

1 mg/ml

Forma del prodotto

Liquid

Formulazione

Supplied in Borate Buffered Saline with 0.1% Sodium Azide.

Conservazione

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Note generali

Mouse anti Human C7 antibody, clone 030-113.7.5.4 recognises complement component 7 (C7), a 110 kDa glycoprotein present in the blood serum. The factor I domain of C7 binds the C terminus of the C5 alpha-chain, acting as a membrane anchor. This enables the assembly of the complement membrane attack complex (MAC) and consequent complement lytic activity. C7 deficiency is associated with increased susceptibility to recurrent infections, in particular by Neisseria meningitides. Mouse anti Human C7 antibody, clone 030-113.7.5.4 does not recognie membrane bound complement membrane attack complex.Mouse anti Human C7 antibody, clone 030-113.7.5.4 inhibits lysis of sensitised sheep erythrocytes.Removal of Sodium Azide is recommended prior to use in functional assays.

Sinonimi

CO7_HUMAN, complement component 7, Complement component C7

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Secondari adatti

Dichiarazione di non responsabilità

Questo prodotto è solo per uso di ricerca. Non è inteso per uso diagnostico o terapeutico.