Anti-c-Jun (phospho Ser63) Anticorpo (A283578)

Anti-c-Jun (phospho Ser63) Antibody

Rabbit polyclonal antibody to c-Jun (phospho Ser63).

This antibody recognises proto-oncogene c-Jun, also known as V-jun avian sarcoma virus 17 oncogene homolog and p39, when phosphorylated at serine 63.c-Jun is a member of the Jun family of transcription factors and is a subunit of the AP-1 transcription factor. c-Jun dimerizes with c-Fos, JDP and ATF family members to form the AP-1 transcription factor. AP-1 is activated by a variety of stimuli including cytokines, stress and growth factors and plays a critical role in cellular processes ranging from proliferation to apoptosis.c-Jun is phosphorylated at serine 63 and serine 73 by MAPK8 (SAPK1/JNK1) and PLK3, resulting in c-Jun mediated transcription (Wang et al. 2007, Vleugel et al. 2006). c-Jun has been implicated in early tumor development, invasion and metastasis while c-Jun phosphorylated at serine 63 has been proposed to play a role in intestinal tumor progression.

WB

WB: 1:500 - 1:2,000

Human

Phospho-specific peptide corresponding to residues surrounding Ser63 of human c-Jun.

Rabbit

Polyclonal

IgG

Unconjugated

Liquid

Supplied in Phosphate Buffered Saline with 0.05% ProClin 300 and 50% Glycerol.

Store undiluted at -20°C. Storage in frost free freezers is not recommended. Avoid freeze-thaw cycles. Should this product contain a precipitate we recommend microcentrifugation before use.

Rabbit anti c-Jun (pSer63) antibody recognizes proto-oncogene c-Jun, also known as V-jun avian sarcoma virus 17 oncogene homolog and p39, when phosphorylated at serine 63.c-Jun is a member of the Jun family of transcription factors and is a subunit of the AP-1 transcription factor. c-Jun dimerizes with c-Fos, JDP and ATF family members to form the AP-1 transcription factor. AP-1 is activated by a variety of stimuli including cytokines, stress and growth factors and plays a critical role in cellular processes ranging from proliferation to apoptosis.c-Jun is phosphorylated at serine 63 and serine 73 by MAPK8 (SAPK1/JNK1) and PLK3, resulting in c-Jun mediated transcription (Wang et al. 2007, Vleugel et al. 2006). c-Jun has been implicated in early tumor development, invasion and metastasis while c-Jun phosphorylated at serine 63 has been proposed to play a role in intestinal tumor progression (Madeo et al. 2010).

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