Anti-beta III Spectrin Anticorpo [SPTBN2/1583] (A250045)

Anti-beta III Spectrin Antibody [SPTBN2/1583]

Mouse monoclonal [SPTBN2/1583] antibody to beta III Spectrin .

Spectrin is an actin binding protein that is a major component of the plasma membrane skeleton. Spectrins function as membrane organizers and stabilizers by forming dimers, tetramers and higher polymers. Vertebrate spectrins have two alpha-subunits (alpha-I/alpha-II) four beta-subunits (beta-I-beta-IV) and a beta-H subunit creating diversity and specialization of function. Spectrin and spectrin are present in erythrocytes, whereas spectrin II (also designated fodrin ) and spectrin I (also designated fodrin ) are present in other somatic cells. The spectrin tetramers in erythrocytes act as barriers to lateral diffusion, but spectrin dimers seem to lack this function. Spectrin III is highly homologous to both spectrin I and spectrin II. Spectrin III is highly expressed in brain, kidney, pancreas and liver, and at lower levels in lung and placenta. Spectrin beta 3 is primarily expressed in nervous tissues with highest expression levels in the cerebellum, where it is found in Purkinje cell soma and dendrites.

Flow Cytometry, WB, IHC-P

Flow Cytometry: 1-2 µg/million cells, IF: 1-2 µg/ml, WB: 1-2 µg/ml, IHC-P: 1-2 µg/ml

Human

Recombinant fragment, around amino acids 356-475, of human SPTBN2 protein. The exact sequence is proprietary.

Mouse

Monoclonal

SPTBN2/1583

IgG2b

Unconjugated

Protein A/G chromatography.

200 µg/ml

246 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-beta III Spectrin Antibody [SPTBN2/1583] - BSA and Azide free (A253225).

Glutamate transporter EAAT4 associated protein 41, GTRAP41, SCA 5, SCA5, SCAR14, Spectrin beta chain brain 2, Spectrin beta III sigma 2, Spectrin beta non erythrocytic 2, Spectrin non erythroid beta chain 2, Spinocerebellar ataxia 5, Spinocerebellar ataxia 5 protein, SPTBN 2, SPTBN2