Ricombinante Anti-beta 2 Microglobulin Anticorpo [rB2M/7279] (A314503)

Anti-beta 2 Microglobulin Antibody [rB2M/7279]

Recombinant mouse monoclonal [rB2M/7279] antibody to beta 2 Microglobulin.

Recognizes a protein of 12kDa, identified as beta-2 microglobulin. Major histocompatibility complex (MHC) class 1 molecules bind to antigens for presentation on the surface of cells. The proteasome is responsible for producing these antigens from the components of foreign pathogens. MHC class 1 molecules consist of an alpha heavy chain that contains three subdomains (alpha1, alpha2, alpha3) and a non-covalent associating light chain, known as beta-2-Microglobulin. Beta-2-Microglobulin associates with the alpha3 subdomain of the alpha heavy chain and forms an immunoglobulin domain-like structure that mediates proper folding and expression of MHC class 1 molecules. The alpha1 and alpha2 domains of the alpha heavy chain form the peptide antigen-binding cleft. Mutations in the beta-2-Microglobulin gene can enhance the progression of malignant melanoma phenotypes.

IHC-P

Raji, HL-60 or HeLa cells. Human carcinomas of stomach, cervix, endometrial, kidney or colon.

IHC: 1-2 µg/ml

Human, Non-Human Primates

Recombinant full-length human B2M protein.

Mouse

Monoclonal

rB2M/7279

kappa

Unconjugated

Protein A chromatography.

200 µg/ml

12 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

B2M, B2MG_HUMAN, Beta 2 microglobin, Beta 2 microglobulin precursor , Beta chain of mhc class 1 proteins , Beta chain of MHC class I molecules, Beta-2-microglobulin form pI 5.3, CDABP0092, Hdcma22p, IMD43