Ricombinante Anti-beta 2 Microglobulin Anticorpo [B2M/1857R] (A249754)

Anti-beta 2 Microglobulin Antibody [B2M/1857R]

Recombinant rabbit monoclonal [B2M/1857R] antibody to beta 2 Microglobulin.

This antibody recognizes a protein of 12kDa, identified as beta-2 microglobulin. Major histocompatibility complex (MHC) class 1 molecules bind to antigens for presentation on the surface of cells. The proteasome is responsible for producing these antigens from the components of foreign pathogens. MHC class 1 molecules consist of an alphaheavy chain that contains three subdomains (alpha1, alpha2, alpha3) and a non-covalent associating light chain, known as beta-2-Microglobulin. Beta-2-Microglobulin associates with the alpha3 subdomain of the alphaheavy chain and forms an immunoglobulin domain-like structure that mediates proper folding and expression of MHC class 1 molecules. The alpha1 and alpha2 domains of the alphaheavy chain form the peptide antigen-binding cleft. Mutations in the beta-2-Microglobulin gene can enhance the progression of malignant melanoma phenotypes.

ELISA, Flow Cytometry, WB

Flow Cytometry: 1-2 µg/million cells, WB: 1-2 µg/ml, IHC: 1-2 µg/ml

Human, Non-Human Primates

Recombinant full-length human B2M protein.

Rabbit

Monoclonal

B2M/1857R

IgG

Protein A chromatography.

200 µg/ml

12 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-beta 2 Microglobulin Antibody [B2M/1857R] - BSA and Azide free (A252934).

B2M, B2MG_HUMAN, Beta 2 microglobin, Beta 2 microglobulin precursor , Beta chain of mhc class 1 proteins , Beta chain of MHC class I molecules, Beta-2-microglobulin form pI 5.3, CDABP0092, Hdcma22p, IMD43