Ricombinante Anti-BCMA Anticorpo [rCD269/8507] (A314493)

Anti-BCMA Antibody [rCD269/8507]

Recombinant mouse monoclonal [rCD269/8507] antibody to BCMA.

The B cell maturation protein (BCMA) is a type I integral membrane protein that belongs to the tumor necrosis factor receptor (TNF-R) superfamily. It is expressed as a 184 amino acid peptide that is expressed only in mature B-lymphocytes and is located on the cis part of the Golgi apparatus. BCMA shares significant homology with TACI (transmembrane activator) within the cysteine-rich domain. TACI has been shown to bind CAML, which induces activation of NFAT (nuclear factor of activated T cells). Both BCMA and TACI have been shown to bind APRIL and TALL-1, which stimulate B cell proliferation in conjunction with other B-cell activators. When overexpressed, TALL-1 stimulates the development of systemic lupus erythaematosus (SLE).

ELISA, IHC-P

NAMALWA cells. Tonsil or gastric carcinoma (IHC).

IHC: 1-2 µg/ml

Human

Recombinant human CD269 protein fragment (around Amino Acids 1-184). The exact sequence is proprietary.

Mouse

Monoclonal

rCD269/8507

kappa

Unconjugated

Protein A/G chromatography.

200 µg/ml

20 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

B cell maturation antigen, B cell maturation factor, B cell maturation protein, B-cell maturation protein, BCM, CD269, CD269 antigen, TNFRSF17, TNR17_HUMAN, Tumor necrosis factor receptor superfamily member 17