This antibody recognises CD257, a ~31 kDa protein. CD257 is also known as B cell activating factor (BAFF), tumor necrosis factor superfamily 13B (TNFSF13B), B lymphocyte stimulator (BLyS) and TNF and APOL-related leukocyte expressed ligand. CD257 is a type 2 transmembrane protein which can be cleaved proteolyically to form a soluble protein. CD257 exerts anti-apoptotic effects and promotes B cell survival via CD267 (TACI), CD269 (BCMA) and CD268 (BAFFR) receptors, the latter interaction playing a critical role in the activation, survival, differentiation and proliferation of B cells.

Applicazioni

ELISA, WB

Reattività

Human

Immunogeno

E. coli derived recombinant protein corresponding to amino acids 134-285 of human CD257.

Sequenza

AVQGPEETVTQDCLQLIADSETPTIQKGSYTFVPWLLSFKRGSALEEKENKILVKETGYFFIYGQVLYTDKTYAMGHLIQRKKVHVFGDELSLVTLFRCIQNMPETLPNNSCYSAGIAKLEEGDELQLAIPRENAQISLDGDVTFFGALKLL

Specie ospite

Mouse

Clonalità

Monoclonal

Clona ID

A01-1A12

Isotipo

IgG2a

Coniugare

Unconjugated

Purificazione

Protein G affinity chromatography of tissue culture supernatant.

Concentrazione

1 mg/ml

Forma del prodotto

Liquid

Formulazione

Supplied in Phosphate Buffered Saline with <0.1% Sodium Azide.

Conservazione

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Note generali

Mouse anti Human CD257 antibody, clone A01-1A12 recognizes CD257, a ~31 kDa protein. CD257 is also known as B cell activating factor (BAFF), tumor necrosis factor superfamily 13B (TNFSF13B), B lymphocyte stimulator (BLyS) and TNF and APOL-related leukocyte expressed ligand. CD257 is a type 2 transmembrane protein which can be cleaved proteolyically to form a soluble protein. CD257 exerts anti-apoptotic effects and promotes B cell survival via CD267 (TACI), CD269 (BCMA) and CD268 (BAFFR) receptors, the latter interaction playing a critical role in the activation, survival, differentiation and proliferation of B cells (Mackay & Schneider, 2009).

Sinonimi

ApoL related ligand TALL 1, B cell Activating Factor, B lymphocyte stimulator, B-cell-activating factor, BLyS, CD 257, CD257, CD257 antigen, Delta BAFF, Dendritic cell derived TNF like molecule, Dendritic cell-derived TNF-like molecule, DTL, DTL precursor, PRO738, soluble form, TALL 1, TALL-1, TALL1, THANK, TN13B_HUMAN, TNF and APOL related leukocyte expressed ligand 1, TNF homolog that activates apoptosis, TNF homolog that activates apoptosis NKFB and JNK., TNF- and APOL-related leukocyte expressed ligand 1, TNFSF13B, TNFSF20, TNLG7A, Tumor necrosis factor (ligand) superfamily member 13b, Tumor necrosis factor ligand 7A, Tumor necrosis factor ligand superfamily member 13b, Tumor necrosis factor ligand superfamily member 20, Tumor necrosis factor like protein ZTNF4, Tumor necrosis factor superfamily member 13B, UNQ401, ZTNF4

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Dichiarazione di non responsabilità

Questo prodotto è solo per uso di ricerca. Non è inteso per uso diagnostico o terapeutico.