Anti-BAFF Anticorpo [2B] (A279179)

Anti-BAFF Antibody [2B] - BSA and Azide free

Mouse monoclonal [2B] antibody to BAFF.

This antibody recognises CD257, also known as BAFF/BLyS. CD257 is a 285 amino acid type II transmembrane protein and member of the tumor necrosis factor (TNF) superfamily of ligands, which acts as a B and T cell stimulator and plays a role in the development of autoimmune diseases such as systemic lupus erythematosus. CD257 is expressed by monocytes, macrophages, T cells and dendritic cells and acts through binding to CD267 (TACI), CD269 (BCMA) and CD268 (BAFFR) receptors, the latter interaction playing a critical role in the activation, survival, differentiation and proliferation of B cells. Mouse anti Human CD257 antibody, clone 2B has not been cross-adsorbed and may react with homologous proteins from related species.

ELISA

ELISA: 5 - 6 µg/ml

Human

Recombinant 17 kDa polypeptide corresponding to the TNF-like portion of the extracellular domain of human CD257, expressed in E. coli.

Mouse

Monoclonal

2B

IgG1

Unconjugated

Protein G affinity chromatography of tissue culture supernatant.

Lyophilized

Reconstitute with 0.5 ml of distilled water.

Supplied in Phosphate Buffered Saline.

Lyophilized: Store at -20°C. Reconstituted: Store undiluted at -20°C, avoid freeze / thaw cycles. Storage in frost free freezers is not recommended. Should this product contain a precipitate we recommend microcentrifugation before use.

Mouse anti Human CD257 antibody, clone 2B recognises CD257, also known as BAFF/BLyS. CD257 is a 285 amino acid type II transmembrane protein and member of the tumor necrosis factor (TNF) superfamily of ligands, which acts as a B and T cell stimulator and plays a role in the development of autoimmune diseases such as systemic lupus erythematosus. CD257 is expressed by monocytes, macrophages, T cells and dendritic cells and acts through binding to CD267 (TACI), CD269 (BCMA) and CD268 (BAFFR) receptors, the latter interaction playing a critical role in the activation, survival, differentiation and proliferation of B cells. Mouse anti Human CD257 antibody, clone 2B has not been cross-adsorbed and may react with homologous proteins from related species.

ApoL related ligand TALL 1, B cell Activating Factor, B lymphocyte stimulator, B-cell-activating factor, BLyS, CD 257, CD257, CD257 antigen, Delta BAFF, Dendritic cell derived TNF like molecule, Dendritic cell-derived TNF-like molecule, DTL, DTL precursor, PRO738, soluble form, TALL 1, TALL-1, TALL1, THANK, TN13B_HUMAN, TNF and APOL related leukocyte expressed ligand 1, TNF homolog that activates apoptosis, TNF homolog that activates apoptosis NKFB and JNK., TNF- and APOL-related leukocyte expressed ligand 1, TNFSF13B, TNFSF20, TNLG7A, Tumor necrosis factor (ligand) superfamily member 13b, Tumor necrosis factor ligand 7A, Tumor necrosis factor ligand superfamily member 13b, Tumor necrosis factor ligand superfamily member 20, Tumor necrosis factor like protein ZTNF4, Tumor necrosis factor superfamily member 13B, UNQ401, ZTNF4