Anti-alpha B Crystallin Anticorpo [2E8] (A278872)

$480

Anticorpo monoclonale [2E8] di topo contro alpha B Crystallin per WB e ELISA.

Spese di spedizione
Tempi di consegna
4-6 Giorni lavorativi
Telefono
+1 (314) 370-6046
Lun - Ven, 8:00 - 16:00 AST
E-mail
orders@antibodies.com
Nome
Anti-alpha B Crystallin Antibody [2E8]
Descrizione
Mouse monoclonal [2E8] antibody to alpha B Crystallin.
Specificità
This antibody recognises the basic (b) form of alpha crystallin, alpha B crystallin, a 20kDa water-soluble major structural protein and member of the heat shock protein family, designated HSPB5, which acts as a molecular chaperone and plays a role in the maintenance of ocular lens transparency/refractive index.Besides the involvement of both alpha A and alpha B crystallin in the prevention of protein precipitation and cataract formation in the eye, alpha crystallins have also been demonstrated in other tissues including the heart, brain, kidney, spleen and thymus. Mutation in alpha B crystallin is responsible for desmin-related myopathy and cataract 16 (Perng et al. 1999.). Alpha B crystallin is also a major component of the astrocytic inclusions known as "Rosenthal fibers" found in Alexander's disease.
Applicazioni
WB, ELISA
Diluizioni consigliate
WB: 1:1,000 - 1:2,000
Reattività
Human, Mouse
Immunogeno
Recombinant human alpha B crystallin (amino acids 1-175) purified from E. coli.
Sequenza
MDIAIHHPWIRRPFFPFHSPSRLFDQFFGEHLLESDLFPTSTSLSPFYLRPPSFLRAPSWFDTGLSEMRLEKDRFSVNLDVKHFSPEELKVKVLGDVIEVHGKHEERQDEHGFISREFHRKYRIPADVDPLTITSSLSSDGVLTVNGPRKQVSGPERTIPITREEKPAVTAAPKK
Specie ospite
Mouse
Clonalità
Monoclonal
Clona ID
2E8
Isotipo
IgG2b
Coniugare

Unconjugated

Purificazione
Protein G affinity chromatography of ascites.
Concentrazione
1 mg/ml
Peso molecolare
Approximately 20 kDa in mouse eye cell lysates.
Forma del prodotto
Liquid
Formulazione
Supplied in Phosphate Buffered Saline with 10% Glycerol and 0.02% Sodium Azide.
Conservazione
Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.
Note generali
Mouse anti Human alpha B crystallin, clone 2E8 recognizes the basic (b) form of alpha crystallin, alpha B crystallin, a 20kDa water-soluble major structural protein and member of the heat shock protein family, designated HSPB5, which acts as a molecular chaperone and plays a role in the maintenance of ocular lens transparency/refractive index.Besides the involvement of both alpha A and alpha B crystallin in the prevention of protein precipitation and cataract formation in the eye, alpha crystallins have also been demonstrated in other tissues including the heart, brain, kidney, spleen and thymus. Mutation in alpha B crystallin is responsible for desmin-related myopathy and cataract 16 (Perng et al. 1999.). Alpha B crystallin is also a major component of the astrocytic inclusions known as "Rosenthal fibers" found in Alexander's disease (Iwaki et al. 1989).
Sinonimi
AACRYA, Alpha crystallin B chain, Alpha(B)-crystallin, Alpha-crystallin B chain, CRYA2, Cryab, CRYAB_HUMAN, Crystallin alpha B, Crystallin alpha polypeptide 2, CTPP2, Heat shock 20 kD like protein, Heat shock protein beta 5, Heat shock protein beta-5, HspB5, Renal carcinoma antigen NY REN 27, Renal carcinoma antigen NY-REN-27, Rosenthal fiber component
Dichiarazione di non responsabilità
Questo prodotto è solo per uso di ricerca. Non è inteso per uso diagnostico o terapeutico.

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