Anti-alpha Actinin 4 Anticorpo [93] (A250399)

Anti-alpha Actinin 4 Antibody [93]

Mouse monoclonal [93] antibody to alpha Actinin 4.

The spectrin gene family encodes a diverse group of cytoskeletal proteins that include spectrins, dystrophins and -actinins. There are four tissue-specific -actinins, namely -actinin-1, -actinin-2, -actinin-3 and -actinin-4, which are localized to muscle and non-muscle cells, including skeletal, cardiac and smooth muscle cells, as well as within the cytoskeleton. Each -actinin protein contains one Actin-binding domain, two calponin-homology domains, two EF-hand domains and four spectrin repeats, through which they function as bundling proteins that can cross-link F-Actin, thus anchoring Actin to a variety of intracellular structures. Defects in the gene encoding -actinin-4 are the cause of focal segmental glomerulosclerosis 1 (FSGS1), a common renal lesion characterized by decreasing kidney function and, ultimately, renal failure.

IHC-P

IHC-P: 1-2 µg/ml

Human

Recombinant full-length human ACTN4 protein.

Mouse

Monoclonal

93

IgG

Protein A/G chromatography.

200 µg/ml

105 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-alpha Actinin 4 Antibody [93] - BSA and Azide free (A253579).

actinin 4, Actinin alpha 4, actinin4, ACTN 4, ACTN4, ACTN4_HUMAN, Alpha-actinin-4, DKFZp686K23158, F actin cross linking protein, F-actin cross-linking protein, Focal segmental glomerulosclerosis 1, FSGS, FSGS 1, FSGS1, Non muscle alpha actinin 4, Non-muscle alpha-actinin 4