Anti-ACTH Antibody (A282687)

Anti-ACTH Antibody

Rabbit polyclonal antibody to ACTH.

This antibody recognises human adrenocorticotrophic hormone, also known as corticotrophin. ACTH is a 4.5 kDa hormone derived from cleavage of pro-opiomelanocortin (POMC), produced in the pituitary gland in response to corticotrophin releasing hormone (CRH) activity and functions to stimulate release of adrenal cortisol. recognises the ACTH cleavage fragment a-melanocyte stimulating hormone (a-MSH), responsible for melanin pigmentation control in most vertebrate species. Rabbit anti Human ACTH does not recognize the C-terminal ACTH cleavage product, corticotropin-like intermediary peptide (CLIP).

ELISA, IHC-Fr, IHC-P, IF

ELISA: 1:500 - 1:1,000, IHC-Fr: 1:100 - 1:200, IHC-P: 1:100 - 1:200

Human, Broad, Rat

Synthetic peptide sequence SYSMEHFRWGKPVGKKRRPVKVYP corresponding to amino acids 1-24 of ACTH conjugated to Keyhole Limpet Haemocyanin.

SYSMEHFRWGKPVGKKRRPVKVYP

Rabbit

Polyclonal

IgG

5 mg/ml

Liquid

Supplied in Phosphate Buffered Saline with 0.09% Sodium Azide.

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Rabbit anti Human ACTH antibody recognizes human adrenocorticotrophic hormone, also known as corticotrophin. ACTH is a 4.5 kDa hormone derived from cleavage of pro-opiomelanocortin (POMC), produced in the pituitary gland in response to corticotrophin releasing hormone (CRH) activity and functions to stimulate release of adrenal cortisol. Rabbit anti Human ACTH polyclonal antibody is directed against the N-terminal portion of adrenocorticotrophic hormone and also recognizes the ACTH cleavage fragment a-melanocyte stimulating hormone (a-MSH), responsible for melanin pigmentation control in most vertebrate species (Fiordelisio et al. 2006). Rabbit anti Human ACTH does not recognize the C-terminal ACTH cleavage product, corticotropin-like intermediary peptide (CLIP).

Corticotropin-lipotropin, Pro-opiomelanocortin