Ricombinante Anti-ACE2 Anticorpo [ACE2/8748R] (A314431)

Anti-ACE2 Antibody [ACE2/8748R]

Recombinant rabbit monoclonal [ACE2/8748R] antibody to ACE2.

Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II toangiotensin 1-7, a vasodilator. Also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. By cleavage ofangiotensin II, may be an important regulator of heart function. By cleavage of angiotensin II, may also have a protective role in acute lung injury. Plays an important role in amino acid transport by acting as binding partner of amino acid transporter SL6A19 in intestine, regulating trafficking, expression on the cell surface, and its catalytic activity In case of human coronaviruses SARS and HCoV-NL63 infections, serve as functional receptor for the spike glycoprotein of both coronaviruses.

ELISA, IHC-P

Human kidney, heart, testis or small intestine.

IHC: 1-2 µg/ml

Human

Recombinant fragment (around Amino Acids 705-805) of human ACE2. The exact sequence is proprietary.

Rabbit

Monoclonal

ACE2/8748R

IgG

Unconjugated

Protein A/G chromatography.

200 µg/ml

92 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

ACE 2, ACE related carboxypeptidase, ACE-related carboxypeptidase, ACE2_HUMAN, ACEH, Angiotensin Converting Enzyme 2, Angiotensin converting enzyme homolog, Angiotensin converting enzyme like protein, Angiotensin I Converting Enzyme (peptidyl dipeptidase A) 2, Angiotensin I converting enzyme 2, Angiotensin-converting enzyme homolog, DKFZP434A014, EC 3.4.17, metalloprotease MPROT 15, Metalloprotease MPROT15, OTTHUMP00000022963, Processed angiotensin-converting enzyme 2