Anti-IRAKM Antibody (A283157)

Anti-IRAKM Antibody

Rabbit polyclonal antibody to IRAKM.

This antibody recognises human Interleukin-1 receptor-associated kinase 3 (IRAK3), a member of the IRAK/Pelle family. IRAKs associate with the IL1/Toll receptors after IL-1 or LPS stimulation, thereby playing an important role in the inflammatory response.IRAK3 inhibits the dissociation of IRAK1 and IRAK4 from the Toll-like receptor signalling complex by either inhibiting the phosphorylation of IRAK1 and IRAK4 or stabilising the receptor complex. It is predominantly expressed in peripheral blood lymphocytes. Defects in the IRAK3 gene are associated with susceptibility to asthma-related traits type 5.Rabbit anti Human IRAK3 antibody does not cross-react with IRAK or IRAK2.

WB, IHC-P

IHC-P 1: 2 µg/ml, WB: 0.5 - 1 µg/ml

Human, Mouse, Rat

A peptide corresponding to amino acids from the C-terminus of human IRAK3.

Rabbit

Polyclonal

IgG

Unconjugated

1 mg/ml

Liquid

Supplied in Phosphate Buffered Saline with 0.02% Sodium Azide.

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Rabbit anti Human IRAK3 antibody recognizes human Interleukin-1 receptor-associated kinase 3 (IRAK3), a member of the IRAK/Pelle family. IRAKs associate with the IL1/Toll receptors after IL-1 or LPS stimulation, thereby playing an important role in the inflammatory response.IRAK3 inhibits the dissociation of IRAK1 and IRAK4 from the Toll-like receptor signalling complex by either inhibiting the phosphorylation of IRAK1 and IRAK4 or stabilising the receptor complex. It is predominantly expressed in peripheral blood lymphocytes. Defects in the IRAK3 gene are associated with susceptibility to asthma-related traits type 5.Rabbit anti Human IRAK3 antibody does not cross-react with IRAK or IRAK2.

ASRT5, IL 1 receptor associated kinase M, IL-1 receptor-associated kinase M, IL1 receptor associated kinase M, Interleukin 1 receptor associated kinase 3, Interleukin 1 receptor associated kinase M, Interleukin-1 receptor-associated kinase 3, IRAK M, IRAK-3, IRAK-M, Irak3, IRAK3_HUMAN