Recombinant Anti-Insulin Antibody [rIRDN/8546] (A315191)

Anti-Insulin Antibody [rIRDN/8546]

Recombinant mouse monoclonal [rIRDN/8546] antibody to Insulin.

Recognizes a polypeptide which is identified as insulin, a 51-amino acid polypeptide composed of A and B chains connected through the C-peptide. Proinsulin, which has very little biological activity, is cleaved by proteases within its cell of origin into the insulin molecule and the C-terminal basic residue. Insulin enhances membrane transport of glucose, amino acids, and certain ions. It also promotes glycogen storage, formation of triglycerides, and synthesis of proteins and nucleic acids. Deficiency of insulin results in diabetes mellitus. The main storage site for insulin is the pancreatic islets. Antibodies to insulin are important as beta-cell and insulinoma marker.

MIA PaCa-2 cells. Pancreas tissue.

IHC: 0.1-0.2 µg/ml

Human

Recombinant full-length human Insulin protein.

Mouse

Monoclonal

rIRDN/8546

IgG2a

Unconjugated

Protein A/G chromatography.

200 µg/ml

6 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

IDDM, IDDM1, IDDM2, ILPR, ins, Insulin A chain, Insulin B chain, INS_HUMAN, IRDN, MODY10, Preproinsulin, Proinsulin, Proinsulin precursor