Anti-IL-15 Antibody [IL15/4353] (A277675)

Anti-IL-15 Antibody [IL15/4353]

Mouse monoclonal [IL15/4353] antibody to IL-15.

Interleukin-15 (IL-15), also designated IL-T, is a cloned cytokine which shares several biological activities but no sequence homology with IL-2. Human, mouse and simian IL-15 cDNA clones have been isolated and characterized. All 3 species encode a 162 amino acid residue precursor protein containing a 48 amino acid leader that is cleaved to generate the mature form of IL-15. IL-15 stimulates the proliferation of T cells and NK cells, while enhancing B cell expansion and antibody production. Unlike IL-2, IL-15 is not produced by lymphocytes, but appears to be produced by macrophages, epithelial lines, muscle and placenta. IL-15 has also been shown to be a chemoattractant for human blood T lymphocytes and to be able to induce lymphokine-activated killer (LAK) activity in NK cells as well as to be able to induce the generation of cytolytic effector cells. Studies have shown that IL-15 is the only other cytokine that shares the β signaling subunit of the IL-2R. Evidence also suggests that like IL-2, IL-4 and IL-7, IL-15 utilizes the common IL-2Rγ subunit.

IHC-P: 1-2 µg/ml

Human

Recombinant fragment corresponding to human IL-15. The exact sequence is proprietary.

Mouse

Monoclonal

IL15/4353

IgG1

Unconjugated

Protein A/G chromatography.

200 µg/ml

14-15 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-IL-15 Antibody [IL15/4353] - BSA and Azide free (A278263).

IL 15, IL15, IL15_HUMAN, Interleukin 15, Interleukin-15, Interleukin15, MGC9721