Anti-IL-10 Antibody [IL10/8711] (A315145)

Anti-IL-10 Antibody [IL10/8711]

Mouse monoclonal [IL10/8711] antibody to IL-10.

Interleukin 10 (IL10) is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immuno-regulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II antigens, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immuno-regulator in the intestinal tract. Mutations in this gene are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis.

Human adrenal or lymph node tissues (IHC).

IHC: 1-2 µg/ml

Human

Recombinant full-length human Interleukin 10 (IL10) protein.

Mouse

Monoclonal

IL10/8711

IgG1

Unconjugated

Protein A chromatography.

200 µg/ml

20 kDa (Monomer) / 37 kDa (Dimer)

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

CSIF, Cytokine synthesis inhibitory factor, GVHDS, IL 10, IL10, IL10A, IL10_HUMAN, Interleukin 10 , Interleukin-10, Interleukin10, MGC126450, MGC126451, T cell growth inhibitory factor, T-cell growth inhibitory factor, TGIF