Anti-IGF1 Receptor Antibody [1H7] - BSA and Azide free (A279118)

Anti-IGF1 Receptor Antibody [1H7] - BSA and Azide free

Mouse monoclonal [1H7] antibody to IGF1 Receptor.

This antibody recognises human CD221, a ~155 kDa receptor tyrosine kinase, also known as Insulin-like growth factor I receptor (IGF-I Receptor). CD221 is composed of two extracellular alpha-subunits and two transmembrane beta-subunits. Clone 1H7 recognises an epitope in the alpha subunits of CD221, demonstrated by western blotting. CD221 is expressed in a range of tissues, including kidney, liver, placenta, mammary gland, brain, ovary and skin.The ligands for CD221 include IGF-I and IGF-II, which bind to CD221 and activate tyrosine kinase activity, resulting in phosphorylation of several intracellular signaling proteins. Clone 1H7 is reported to partially block binding of IGF-I and IGF-II to CD221.

IHC-P, WB, Flow Cytometry, Functional Assays

Flow Cytometry: 1:10, IHC-P: 1:10 - 1:40, Use 10µl of the suggested working dilution to label 10⁶ cells in 100µl

Human

Purified human placental IGF-I receptor.

Mouse

Monoclonal

1H7

IgG1

1 mg/ml

Liquid

Supplied in Phosphate Buffered Saline.

Store undiluted at -20°C only. Storage in frost free freezers is not recommended. Avoid freeze-thaw cycles. Should this product contain a precipitate we recommend microcentrifugation before use.

Mouse anti Human CD221 antibody, clone 1H7 recognizes human CD221, a ~155 kDa receptor tyrosine kinase, also known as Insulin-like growth factor I receptor (IGF-I Receptor). CD221 is composed of two extracellular alpha-subunits and two transmembrane beta-subunits. Clone 1H7 recognizes an epitope in the alpha subunits of CD221, demonstrated by western blotting (Li et al.1993).CD221 is expressed in a range of tissues, including kidney, liver, placenta, mammary gland, brain, ovary and skin.The ligands for CD221 include IGF-I and IGF-II, which bind to CD221 and activate tyrosine kinase activity, resulting in phosphorylation of several intracellular signaling proteins. Clone 1H7 is reported to partially block binding of IGF-I and IGF-II to CD221 (Li et al.1993).

CD221, IGF-I receptor, Insulin-like growth factor 1 receptor, Insulin-like growth factor I receptor