Anti-iASPP Antibody (A283103)

Anti-iASPP Antibody

Rabbit polyclonal antibody to iASPP.

This antibody recognises human inhibitor of apoptosis stimulating protein of p53 (iASPP), which plays a central role in regulation of apoptosis and transcription via its interaction with NFkB and p53 proteins. At present, the iASPP gene is thought to encode three isoforms; isoform 1 is predominantly located in the cytoplasm, whilst isoforms 2 and 3 are nuclear proteins. iASPP is highly expressed in the heart, placenta and prostate.iASPP has been shown to have oncogenic properties in human breast carcinomas.

WB, IHC-P, ELISA

ELISA: 1:40,000 - 1:160,000, WB: 1:1,000 - 1:5,000

Human, Mouse, Dog

Synthetic peptide corresponding to amino acids 780-797 of human iASPP (isoform 1) protein.

REGESVTVLRRDGPEETD

Rabbit

Polyclonal

IgG

Unconjugated

Approximately 100 and 50 kDa corresponding to iASPP isoforms 1 and 2 respectively.

Liquid

Supplied in Phosphate Buffered Saline with <0.1% Sodium Azide.

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Rabbit anti Human iASPP antibody detects human inhibitor of apoptosis stimulating protein of p53 (iASPP), which plays a central role in regulation of apoptosis and transcription via its interaction with NFkB and p53 proteins. At present, the iASPP gene is thought to encode three isoforms; isoform 1 is predominantly located in the cytoplasm, whilst isoforms 2 and 3 are nuclear proteins. iASPP is highly expressed in the heart, placenta and prostate.iASPP has been shown to have oncogenic properties in human breast carcinomas.

inhibitor of apoptosis stimulating protein of p53, Inhibitor of ASPP protein, NFkB interacting protein 1, NKIP1, PPP1R13B-like protein, PPP1R13L, Protein iASPP, protein phosphatase 1 regulatory (inhibitor) subunit 13 like, RAI, RelA-associated inhibitor