Recombinant Anti-Human IgM Heavy Chain Antibody [IGHM/3803R] (A248970)

Anti-Human IgM Heavy Chain Antibody [IGHM/3803R]

Recombinant rabbit monoclonal [IGHM/3803R] antibody to Human IgM Heavy Chain.

This antibody recognizes a protein of 75kDa, identified as mu heavy chain of human immunoglobulins. It does not cross-react with alpha (IgA), gamma (IgG), epsilon (IgE), or delta (IgD), heavy chains, T-cells, monocytes, granulocytes, or erythrocytes. Monomeric IgM is expressed as a membrane bound antibody on the surface of B cells and as a pentamer when secreted by plasma cells. IgM antibody is prominent in early immune responses to most antigens. Aberrant levels are associated with immune deficiency states, hereditary deficiencies, myeloma, Waldenstroms macroglobulinemia, chronic infection and hepatocellular disease. This MAb is useful in the identification of leukemias, plasmacytomas, and certain non-Hodgkin s lymphomas. The most common feature of these malignancies is the restricted expression of a single heavy chain class. Demonstration of clonality in lymphoid infiltrates indicates that the infiltrate is clonal and therefore malignant.

IHC-P: 1-2 µg/ml

Human

Recombinant full-length human IGHM protein.

Rabbit

Monoclonal

IGHM/3803R

Unconjugated

Protein A/G chromatography.

200 µg/ml

50-75 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-Human IgM Heavy Chain Antibody [IGHM/3803R] - BSA and Azide free (A252150).