Anti-HLA DRA Antibody [IPO-10] - BSA and Azide free (A252027)

Mouse monoclonal [IPO-10] antibody to HLA DRA for Flow Cytometry and IF.

Alternative Formats and ConjugatesAlternative Formats

Freight Charges
Lead Time
4-6 Business Days
Telephone
+1 (314) 370-6046
Mon - Fri, 8am - 4pm AST
Email
orders@antibodies.com
Name
Anti-HLA DRA Antibody [IPO-10] - BSA and Azide free
Description
Mouse monoclonal [IPO-10] antibody to HLA DRA.
Specificity
This antibody defines the antigen, which appears on B cell progenitors following HLA-DR and preceding CD10, CD19, CD22, CD37, and cym. It is expressed on resting B cells and than reappears and persists in cytoplasm and on cell surface until cytoplasmic Ig appears. It is a useful antibody for diagnosis of neoplasms of B cell origins. It reacts with human B cell lines Daudi, Raji, Namalva, EB-3, and RPMI-8226 (50% of cells). This antibody does not label T cell lines, blood granulocytes, thymocytes, or bone marrow stromal fibroblasts. No significant changes are detected after PHA or ConA stimulation while LPS and PWM stimulated cultures after 18-48h show decreased number of antigen-positive cells but in final terms of cultivation antigen is expressed again. This antibody labels B cell leukemias and some lymphomas. Hairy cell leukemia strongly reacts and 70% of B cell CLL and some B-NHL were also positive. This antibody reacts with AMML cells and in a majority of Hodgkins disease cases a significant percentage of affected lymph node cells were detected.
Applications
Flow Cytometry, IF
Dilutions
Flow Cytometry: 1-2 µg/million cells, IF: 1-2 µg/ml
Reactivity
Human, Monkey
Immunogen
Spleen cells of a patient with hairy cell leukemia (Daudi cells).
Host
Mouse
Clonality
Monoclonal
Clone ID
IPO-10
Isotype
IgG3
Light Chains
kappa
Conjugate

Unconjugated

Purification
Protein A/G chromatography.
Concentration
1 mg/ml
Molecular Weight
~36 kDa
Product Form
Liquid
Formulation
Supplied in 10mM Phosphate Buffered Saline; without Sodium Azide and carrier free.
Storage
Shipped at 4°C. Store at 4°C.
General Notes
This monoclonal antibody is also available in a different formulation with BSA and Sodium Azide - Anti-HLA DRA Antibody [IPO-10] (A248847).
Synonyms
DR alpha chain, DR alpha chain precursor, DRA_HUMAN, DRB1, DRB4, Histocompatibility antigen HLA DR alpha, HLA class II histocompatibility antigen, HLA class II histocompatibility antigen DR alpha chain, HLA DR1B, HLA DR3B, HLA DRA1, HLA DRB1, HLA DRB3, HLA DRB4, HLA DRB5, HLA-DR, HLA-DRA, HLADR4B, HLADRA1, HLADRB, Major histocompatibility complex class II DR alpha, Major histocompatibility complex class II DR beta 1, Major histocompatibility complex class II DR beta 3, Major histocompatibility complex class II DR beta 4, Major histocompatibility complex class II DR beta 5, MGC117330, MHC cell surface glycoprotein, MHC class II antigen DRA, MHC II, MLRW
Isotype Controls
Disclaimer
This product is for research use only. It is not intended for diagnostic or therapeutic use.
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