Mouse monoclonal [PCRP-HIC2-1B1] antibody to HIC2.
Specificity
HIC2 (HIC ZBTB Transcriptional Repressor 2) is a Protein Coding gene. Diseases associated with HIC2 include Orofaciodigital Syndrome X and Simpson-Golabi-Behmel Syndrome, Type 1. HIC2 contains 5 C2H2-type zinc fingers and 1 BTB (POZ) domain. It belongs to the krueppel C2H2-type zinc-finger protein family, Hic subfamily and is a transcriptional repressor. It is a transcription activator of SIRT1.
HIC1 related gene on chromosome 22, Hic3, HRG22, Hypermethylated in cancer 2 protein, KIAA1020, ZBTB30, Zinc finger and BTB domain-containing protein 30, ZNF907
Flow cytometric analysis of PFA-fixed HeLa cells using Anti-HIC2 Antibody [PCRP-HIC2-1B1] followed by Goat Anti-Mouse IgG (CF® 488) (Blue). Isotype Control (Red).
SDS-PAGE analysis of Anti-HIC2 Antibody [PCRP-HIC2-1B1] under non-reduced and reduced conditions; showing intact IgG and intact heavy and light chains, respectively. SDS-PAGE analysis confirms the integrity and purity of the antibody.
Immunofluorescent analysis of PFA-fixed HeLa cells stained with Anti-HIC2 Antibody [PCRP-HIC2-1B1] followed by Goat Anti-Mouse IgG (CF® 488) (Green). CF® 640A Phalloidin (Red).
Analysis of protein array containing more than 19,000 full-length human proteins using Anti-HIC2 Antibody [PCRP-HIC2-1B1]. Z-Score and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target; a MAb is considered to be specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.
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