Anti-HER4 Antibody [HFR-1] (A248461)

Anti-HER4 Antibody [HFR-1]

Mouse monoclonal [HFR-1] antibody to HER4.

The EGF receptor family comprises several related receptor tyrosine kinases that are frequently overexpressed in a variety of carcinomas. Members of this receptor family include EGFR (HER1), Neu (ErbB-2, HER2), ErbB-3 (HER3) and ErbB-4 (HER4), which form either homodimers or heterodimers upon ligand binding. The gene encoding ErbB-4 is expressed as a full-length protein, which produces a short membrane-anchored cytoplasmic domain fragment and a long ectodomain fragment. The short fragment is heavily tyrosine phosphorylated and possesses tyrosine kinase catalytic activity toward an exogenous substrate. Proteolytic cleavage of ErbB-4 is promoted by the binding of heregulin. ErbB-4 is involved in cell proliferation and differentiation and its expression is highest in breast carcinoma cell lines, normal skeletal muscle, heart, pituitary, brain and cerebellum. Its expression in breast cancer, pediatric brain cancer and other types of carcinomas has been reported in studies which suggest ErbB4 expression is involved in both normal tissue development and carcinogenesis.

Flow Cytometry, IF

Flow Cytometry: 1-2 µg/million cells, IF: 1-2 µg/ml

Human, Mouse

This antibody is predicted to cross react with Rat and Chicken.

Recombinant fragment, around amino acids 1116-1269, of human ERBB4 protein. The exact sequence is proprietary.

Mouse

Monoclonal

HFR-1

IgG2b

kappa

Protein A/G chromatography.

200 µg/ml

180 kDa (precursor) / 80 / 120 kDa (cleaved)

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-HER4 Antibody [HFR-1] - BSA and Azide free (A251643).

4ICD, ALS19, Avian erythroblastic leukemia viral oncogene homolog 4, Avian erythroblastic leukemia viral v erb b2 oncogene homolog 4, E4ICD, EC 2.7.10.1, ErbB 4, Erbb4, ERBB4 intracellular domain, ERBB4_HUMAN, HER 4, human epidermal growth factor receptor 4, Mer4, MGC138404, Oncogene ERBB4, p180erbB4, Proto-oncogene-like protein c-ErbB-4, Receptor protein tyrosine kinase erbB 4 precursor, Receptor tyrosine protein kinase erbB 4, s80HER4, Tyrosine kinase type cell surface receptor HER4, Tyrosine kinase-type cell surface receptor HER4, v erb a avian erythroblastic leukemia viral oncogene homolog like 4, v erb a erythroblastic leukemia viral oncogene homolog 4, v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian), V-ERB-B2 avian erythroblastic leukemia viral oncogene homolog 4, Verba avian erythroblastic leukemia viral oncogene homolog like 4, Verba erythroblastic leukemia viral oncogene homolog 4, VERBB2