Anti-Heparan Sulfate Proteoglycan Antibody [A7L6] (A248894)

Anti-Heparan Sulfate Proteoglycan Antibody [A7L6]

Rat monoclonal [A7L6] antibody to Heparan Sulfate Proteoglycan.

This antibody specifically precipitates heterogeneous material of high MW, identified as perlecan, a major heparan-sulfate proteoglycan (HSPG) within all basement membranes and cell surfaces. It does not cross-react with laminin, fibronectin, or dermatran sulfate proteoglycan. Because of perlecans strategic location and ability to store and protect growth factors, it has been strongly implicated in the control of tumor cell growth and metastatic behavior. Perlecan possesses angiogenic and growth-promoting attributes primarily by acting as a co-receptor for basic fibroblast growth factor (FGF-2). Suppression of perlecan causes substantial inhibition of neoplastic growth and neovascularization. Thus, perlecan is a potent inducer of neoplasm growth and angiogenesis in vivo and therapeutic interventions targeting this key modulator of tumor progression may improve neoplastic treatment.

Flow Cytometry, IF, IHC-P

Flow Cytometry: 1-2 µg/million cells, IF: 1-2 µg/ml, IHC-P: 1-2 µg/ml

Human, Monkey, Bovine, Porcine, Mouse, Fish

Murine EHS laminin preparation.

Rat

Monoclonal

A7L6

IgG2a

Unconjugated

Protein A/G chromatography.

200 µg/ml

>400 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-Heparan Sulfate Proteoglycan Antibody [A7L6] - BSA and Azide free (A252074).