Anti-Heme Oxygenase 1 Antibody (A282805)

Anti-Heme Oxygenase 1 Antibody

Rabbit polyclonal antibody to Heme Oxygenase 1.

This antibody recognises human heme oxygenase-1 (HO-1), a 288 amino acid enzyme with a crucial role in heme catabolism, cleaving the heme ring to form biliverdin which is further processed to form bilirubin by a reductase enzyme. HO-1 activity is highest in the spleen where it is involved in the processing of senescent erythrocytes. HO-1 expression can be increased during cellular stress, including heat shock. Baseline levels of expression are high in certain tissues, including spleen and liver. Enriched enzyme preparations are recommended for experimental analysis.

WB, IHC-Fr

IHC-Fr: 1:50 - 1:1,000, WB: 1:1,000

Human, Bovine, Mouse, Rat, Pig

This antibody does not cross react with Dog

Synthetic peptide sequence HDLSEALKEATKEVHC corresponding to amino acids 12-25 (+C-NH₂ of human heme oxygenase 1.

HDLSEALKEATKEVHC

Rabbit

Polyclonal

IgG

1 mg/ml

Liquid

Supplied in Phosphate Buffered Saline with 0.065% Sodium Azide.

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Rabbit anti Human heme oxygenase 1 antibody recognizes human heme oxygenase-1 (HO-1), a 288 amino acid enzyme with a crucial role in heme catabolism, cleaving the heme ring to form biliverdin which is further processed to form bilirubin by a reductase enzyme. HO-1 activity is highest in the spleen where it is involved in the processing of senescent erythrocytes (Delaby et al. 2012). HO-1 expression can be increased during cellular stress, including heat shock (Ewing et al. 1992). Baseline levels of expression are high in certain tissues, including spleen and liver. Enriched enzyme preparations are recommended for experimental analysis.

HMOX1, HO, HO-1, HO1