Anti-HCG beta Antibody [HCGb/54+ HCGb/459] (A248172)

Anti-HCG beta Antibody [HCGb/54+ HCGb/459]

Mouse monoclonal [HCGb/54+ HCGb/459] antibody to HCG beta.

This antibody reacts with a protein of 22kDa, identified as beta sub-unit of HCG. It does not cross react with the alpha sub-unit. HCG is a glycoprotein, which is secreted in large quantities by normal trophoblasts. It is present only in trace amounts in non-pregnant urine and sera but rises sharply during pregnancy. HCG is composed of two non-identical, non-covalently linked polypeptide chains designated as the subunit is identical to that of thyroid stimulating hormone (TSH) follicle stimulating hormone (FSH), and luteinizing hormone (LH). hCG MAb detects cells and tumors of trophoblastic origin such as choriocarcinoma. Large cell carcinoma and adenocarcinoma of the lung demonstrate anti-hCG positivity in 90% and 60% of cases respectively. 20% of lung squamous cell carcinomas are positive. hCG expression by non-trophoblastic tumors may indicate aggressive behavior.

IHC-P: 1-2 µg/ml

Human

Recombinant hCG beta protein.

Mouse

Monoclonal

HCGb/54+ HCGb/459

IgG1

kappa

Protein A/G chromatography.

200 µg/ml

22 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-HCG beta Antibody [HCGb/54+ HCGb/459] - BSA and Azide free (A251355).

CG beta, CG-beta, CGB, CGB3, CGB5, CGB7, CGB8, CGHB_HUMAN, Choriogonadotropin subunit beta, Chorionic gonadotrophin chain beta, Chorionic gonadotropin beta 3 subunit, Chorionic gonadotropin beta polypeptide, Chorionic gonadotropin beta subunit, hCGB